Department of Clinical Laboratory, Guangxi Academy of Medical Sciences, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021 Guangxi, China.
Department of Clinical Laboratory, Guangxi Hospital of Traditional Chinese Medicine, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, 530023 Guangxi, China.
Biomed Res Int. 2022 Aug 18;2022:5154122. doi: 10.1155/2022/5154122. eCollection 2022.
In recent years, the rate of residents suffering from cardiovascular disease (CVD), disability, and death has risen significantly. The latest report on CVD in China shows that it still has the highest mortality rate of all diseases in that country. Different from linear RNA, circular RNA (circRNA) is a covalently closed transcript, mainly through reverse splicing so that the 3'end and the 5'end are covalently connected to form a closed loop structure. It is structurally stable and abundant and has distinct tissue or cell specificity, and it is widely distributed in eukaryotes. Although circRNAs were discovered many years ago, researchers have only recently begun to slowly discover their extensive expression and regulatory functions in various biological processes. Studies have found that some circRNAs perform multiple functions in cells more used as RNA binding protein or microRNA sponge. In addition, accumulating evidence shows that the first change that occurs in patients with various metabolic diseases such as hypertension and cardiovascular disease is dysregulated circRNA expression. For cardiovascular and other related blood vessels, circRNA is one of the important causes of various complications. These findings contribute to a more comprehensive understanding and grasp of CVD, and the related molecular mechanisms of CVD should be further analyzed. Here, we review the new understanding of circRNAs in CVD and explain the role of these innovative biomarkers in the analysis and determination of other related cardiovascular events such as coronary heart disease. Thus, this study is aimed at providing new ideas and proposing more feasible medical research strategies based on circRNA.
近年来，居民患心血管疾病（CVD）、残疾和死亡的比例显著上升。中国最新的 CVD 报告显示，该病仍然是该国所有疾病中死亡率最高的。与线性 RNA 不同，环状 RNA（circRNA）是一种共价闭合的转录本，主要通过反向剪接使 3'端和 5'端共价连接形成闭环结构。circRNA 结构稳定且丰富，具有明显的组织或细胞特异性，广泛存在于真核生物中。尽管 circRNA 多年前就已被发现，但研究人员直到最近才开始慢慢发现其在各种生物过程中广泛的表达和调控功能。研究发现，一些 circRNA 更多地作为 RNA 结合蛋白或 microRNA 海绵，在细胞中发挥多种功能。此外，越来越多的证据表明，高血压和心血管疾病等各种代谢疾病患者首先发生的变化是 circRNA 表达失调。对于心血管和其他相关血管，circRNA 是各种并发症的重要原因之一。这些发现有助于更全面地了解和掌握 CVD，以及进一步分析 CVD 的相关分子机制。在这里，我们回顾了 circRNA 在 CVD 中的新认识，并解释了这些创新生物标志物在分析和确定其他相关心血管事件（如冠心病）中的作用。因此，本研究旨在基于 circRNA 为提供新的思路并提出更可行的医学研究策略。
