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Microglia activation linking amyloid-β drive tau spatial propagation in Alzheimer's disease.

作者信息

Wang Qing, Xie Chunming

机构信息

Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China.

Institute of Neuropsychiatry, Affiliated ZhongDa Hospital, Southeast University, Nanjing, China.

出版信息

Front Neurosci. 2022 Aug 12;16:951128. doi: 10.3389/fnins.2022.951128. eCollection 2022.

DOI:10.3389/fnins.2022.951128
PMID:36033617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9417618/
Abstract
摘要

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2022 Alzheimer's disease facts and figures.2022 年阿尔茨海默病事实和数据。
Alzheimers Dement. 2022 Apr;18(4):700-789. doi: 10.1002/alz.12638. Epub 2022 Mar 14.
2
Microglia Heterogeneity in Alzheimer's Disease: Insights From Single-Cell Technologies.阿尔茨海默病中的小胶质细胞异质性：来自单细胞技术的见解
Front Synaptic Neurosci. 2021 Dec 23;13:773590. doi: 10.3389/fnsyn.2021.773590. eCollection 2021.
3
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis.斑块相关的寡聚β淀粉样蛋白驱动APP/PS1小鼠海马体早期突触毒性：超微结构病理学分析
Front Neurosci. 2021 Nov 4;15:752594. doi: 10.3389/fnins.2021.752594. eCollection 2021.
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Microglial activation and tau propagate jointly across Braak stages.小胶质细胞活化和 tau 蛋白共同在 Braak 阶段传播。
Nat Med. 2021 Sep;27(9):1592-1599. doi: 10.1038/s41591-021-01456-w. Epub 2021 Aug 26.
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Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.斑块相关的小胶质细胞过度分泌细胞外囊泡，并加速人源化 APP 小鼠模型中的 tau 传播。
Mol Neurodegener. 2021 Mar 22;16(1):18. doi: 10.1186/s13024-021-00440-9.
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Neuroinflammatory Mechanisms in Ischemic Stroke: Focus on Cardioembolic Stroke, Background, and Therapeutic Approaches.缺血性脑卒中的神经炎症机制：关注心源性脑栓塞、背景和治疗方法。
Int J Mol Sci. 2020 Sep 4;21(18):6454. doi: 10.3390/ijms21186454.
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Nat Commun. 2020 Sep 4;11(1):4413. doi: 10.1038/s41467-020-18249-3.
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The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer's disease: a longitudinal PET study.阿尔茨海默病中神经炎症、β-淀粉样蛋白和 tau 沉积之间的关系：一项纵向 PET 研究。
J Neuroinflammation. 2020 May 6;17(1):151. doi: 10.1186/s12974-020-01820-6.
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Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.小胶质细胞通过选择性自噬清除神经元释放的α-突触核蛋白，从而预防神经退行性变。
Nat Commun. 2020 Mar 13;11(1):1386. doi: 10.1038/s41467-020-15119-w.
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Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology.淀粉样蛋白-β（Aβ）斑块促进路易体病伴 Aβ 病理学小鼠模型中α-突触核蛋白和 tau 的播种和扩散。
Neuron. 2020 Jan 22;105(2):260-275.e6. doi: 10.1016/j.neuron.2019.10.010. Epub 2019 Nov 20.