Chen Guiling, Chen Hankun, Zeng Xiang, Zhu Wei
The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Surg. 2022 Aug 12;9:933781. doi: 10.3389/fsurg.2022.933781. eCollection 2022.
Wound healing is a complex and integrated process of the interaction of various components within the injured tissue. Accumulating evidence suggested that stem cell-derived exosomal transcriptomes could serve as key regulatory molecules in wound healing in stem cell therapy. Stem cell-derived exosomal transcriptomes mainly consist of long noncoding RNAs (lncRNAs), microRNAs (miRNAs), circular RNAs (circRNAs) and messenger RNAs (mRNAs). In this article we presented a brief introduction on the wound repair process and exosomal transcriptomes. Meanwhile, we summarized our current knowledge of the involvement of exosomal transcriptomes in physiological and pathological wound repair process including inflammation, angiogenesis, and scar formation.
伤口愈合是受损组织内各种成分相互作用的复杂且整合的过程。越来越多的证据表明，干细胞来源的外泌体转录组在干细胞治疗的伤口愈合中可作为关键调节分子。干细胞来源的外泌体转录组主要由长链非编码RNA（lncRNA）、微小RNA（miRNA）、环状RNA（circRNA）和信使RNA（mRNA）组成。在本文中，我们简要介绍了伤口修复过程和外泌体转录组。同时，我们总结了目前关于外泌体转录组参与生理和病理伤口修复过程（包括炎症、血管生成和瘢痕形成）的知识。
