Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch, Russian Academy of Sciences, Irkutsk, Russia.
Irkutsk Scientific Center for Surgery and Traumatology, Irkutsk, Russia.
Dokl Biochem Biophys. 2022 Aug;505(1):151-155. doi: 10.1134/S1607672922040019. Epub 2022 Aug 29.
The antitumor properties of aqueous extracts of Inonotus rheades basidiomycete mushrooms were evaluated when the fungi were cultured on wood discs and wood shavings (birch) at 25 ± 1°C in the dark and under constant illumination with blue light (12.8 W/m). The aqueous fraction containing water-soluble polysaccharides was isolated and analyzed: WS-5 fraction cultured on wood discs under blue light illumination, WS-8 fraction grown under similar conditions on wood shavings; WS-6 fraction grown in the dark on wood discs; and WS-7 fraction grown under similar conditions on wood shavings. The antitumor effects of the extracts were studied on the model of Ehrlich ascites carcinoma in mice. It was found that the extracts isolated from the basidial fungus Inonotus rheades exhibit antitumor properties and that their accumulation during growth is determined by different cultivation conditions.
评估了在 25 ± 1°C 黑暗条件下和恒定蓝光（12.8 W/m）照射下，香菇在木屑和木片（桦木）上培养时，水提物的抗肿瘤特性。分离并分析了含有水溶性多糖的水相部分：WS-5 级，在蓝光照射下在木片上培养；WS-8 级，在类似条件下在木屑上生长；WS-6 级，在黑暗中在木片上生长；WS-7 级，在类似条件下在木屑上生长。在艾氏腹水癌小鼠模型上研究了提取物的抗肿瘤作用。结果表明，从担子菌香菇中分离出的提取物具有抗肿瘤特性，其在生长过程中的积累取决于不同的培养条件。
