Kedir Welela Meka, Abdi Gamachu Fikadu, Goro Meta Mamo, Tolesa Leta Deressa
Department of Chemistry, College of Natural and Computational Sciences, Mettu University, Mettu, Ethiopia.
Heliyon. 2022 Aug 15;8(8):e10196. doi: 10.1016/j.heliyon.2022.e10196. eCollection 2022 Aug.
Due to their improved structural and functional properties as well as biocompatibility, biodegradability, and nontoxicity, chitosan and its nanoparticles are currently grasping the interest of researchers. Although numerous attempts have been made to apply chitosan and its derivatives to biological applications, few have reported in achieving its pharmacological and drug delivery. The goal of the current work is to provide a summary of the chitosan biopolymer's physical, chemical, and biological properties as well as its synthesis of nanoparticles and characterization of its modified nanocomposites. The drug delivery method and pharmaceutical applications of chitosan biopolymer and its modified nanocomposites are examined in further detail in this research. We will introduce also about the most current publications in this field of study as well as its recent expansion.
由于壳聚糖及其纳米颗粒具有改善的结构和功能特性以及生物相容性、生物降解性和无毒特性,目前正吸引着研究人员的关注。尽管已经进行了许多尝试将壳聚糖及其衍生物应用于生物应用,但很少有报道称其在药理和药物递送方面取得成功。当前工作的目标是总结壳聚糖生物聚合物的物理、化学和生物学特性,以及其纳米颗粒的合成和改性纳米复合材料的表征。本研究将更详细地研究壳聚糖生物聚合物及其改性纳米复合材料的药物递送方法和药物应用。我们还将介绍该研究领域的最新出版物及其近期进展。