Ramchandani Shanaya, Naz Irum, Dhudha Namrata, Garg Manoj
Department of Pharmacology Biomedicine, the University of Melbourne, Parkville Victoria 3010, Australia.
Department of Biochemistry, Quaid-i-Azam University, Higher Education Commission of Pakistan, Islamabad 44000, Pakistan.
Explor Target Antitumor Ther. 2020;1(6):413-426. doi: 10.37349/etat.2020.00026. Epub 2020 Dec 28.
Cancer is one of the leading causes of mortality, contributing to 9.6 million deaths globally in 2018 alone. Although several cancer treatments exist, they are often associated with severe side effects and high toxicities, leaving room for significant advancements to be made in the field. In recent years, several phytochemicals from plants and natural bioresources have been extracted and tested against various human malignancies using both and preclinical model systems. Cardamonin, a chalcone extracted from the species, is an example of a natural therapeutic agent that has anti-cancer and anti-inflammatory effects against human cancer cell lines, including breast, lung, colon, and gastric, in both culture systems as well as xenograft mouse models. Earlier, cardamonin was used as a natural medicine against stomach related issues, diarrhea, insulin resistance, nephroprotection against cisplatin treatment, vasorelaxant and antinociceptive. The compound is well-known to inhibit proliferation, migration, invasion, and induce apoptosis, through the involvement of Wnt/β-catenin, NF-κB, and PI3K/Akt pathways. The good biosafety and pharmacokinetic profiling of cardamonin satisfy it as an attractive molecule for the development of an anticancer agent. The present review has summarized the chemo-preventive ability of cardamonin as an anticancer agent against numerous human malignancies.
癌症是主要的死亡原因之一，仅在2018年全球就有960万人死于癌症。尽管存在多种癌症治疗方法，但它们往往伴随着严重的副作用和高毒性，这使得该领域仍有很大的进步空间。近年来，从植物和天然生物资源中提取了几种植物化学物质，并使用体外和体内临床前模型系统对各种人类恶性肿瘤进行了测试。小豆蔻明是从小豆蔻属植物中提取的一种查耳酮，是一种天然治疗剂，在体外培养系统和异种移植小鼠模型中，对包括乳腺癌、肺癌、结肠癌和胃癌在内的人类癌细胞系具有抗癌和抗炎作用。早期，小豆蔻明被用作治疗胃部相关问题、腹泻、胰岛素抵抗、顺铂治疗的肾保护、血管舒张和抗伤害感受的天然药物。众所周知，该化合物通过Wnt/β-连环蛋白、NF-κB和PI3K/Akt信号通路的参与来抑制增殖、迁移、侵袭并诱导凋亡。小豆蔻明良好的生物安全性和药代动力学特性使其成为开发抗癌药物的有吸引力的分子。本综述总结了小豆蔻明作为抗癌剂对多种人类恶性肿瘤的化学预防能力。
