Obesity Research Group, Department of Clinical and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Centre of Obesity and Innovation (ObeCe), Clinic of Surgery, St. Olav University Hospital, Trondheim, Norway.
Obesity (Silver Spring). 2022 Oct;30(10):1963-1972. doi: 10.1002/oby.23535. Epub 2022 Aug 31.
The aim of this study was to compare changes in hedonic hunger and food reward in individuals with severe obesity achieving 10% to 15% weight loss with a very low-energy diet (VLED) alone or VLED and bariatric surgery.
Patients scheduled for sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) initiated a VLED 2 weeks prior to surgery and continued the diet for 8 weeks postoperatively. BMI-matched controls underwent a VLED for 10 weeks. Hedonic hunger was assessed with the Power of Food Scale, and food reward with the Leeds Food Preference Questionnaire, pre and post intervention.
A total of 44 participants completed the study: 15 SG, 14 RYGB, and 15 controls (61%, 79% and 69% females, respectively; BMI: 40.5 ± 0.5 kg/m ; age: 43.9 ± 1.4 years). Average weight loss was 18.3 ± 0.6 kg (16%), comprising 13.5 ± 0.5 kg fat mass, with no significant differences between groups. Similar reductions in hedonic hunger were observed in all groups. Overall, food reward was similarly reduced in SG and RYGB groups, whereas controls showed little or no change.
Independent of modality, weight loss seems to reduce hedonic hunger, but bariatric surgery leads to several additional favorable changes in food reward and preferences.
本研究旨在比较严重肥胖患者在接受极低能量饮食（VLED）单独或 VLED 联合减重手术治疗后，在 10%至 15%体重减轻时，愉悦性饥饿和食物奖励的变化。
计划接受袖状胃切除术（SG）或 Roux-en-Y 胃旁路术（RYGB）的患者在手术前 2 周开始 VLED，并在术后继续饮食 8 周。BMI 匹配的对照组接受 VLED 治疗 10 周。干预前后采用食物力量量表评估愉悦性饥饿，采用利兹食物偏好问卷评估食物奖励。
共有 44 名参与者完成了研究：15 名 SG、14 名 RYGB 和 15 名对照组（分别为 61%、79%和 69%女性；BMI：40.5±0.5kg/m；年龄：43.9±1.4 岁）。平均体重减轻 18.3±0.6kg（16%），其中包括 13.5±0.5kg 脂肪量，各组间无显著差异。所有组的愉悦性饥饿均有相似程度的降低。总体而言，SG 和 RYGB 组的食物奖励均有相似程度的降低，而对照组则几乎没有变化。
无论治疗方式如何，体重减轻似乎都能降低愉悦性饥饿，但减重手术会导致食物奖励和偏好方面的其他几个有利变化。
