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角质形成细胞 PIEZO1 调节皮肤机械感觉。

Keratinocyte PIEZO1 modulates cutaneous mechanosensation.

机构信息

Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Wauwatosa, United States.

出版信息

Elife. 2022 Sep 2;11:e65987. doi: 10.7554/eLife.65987.

DOI:10.7554/eLife.65987
PMID:36053009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9512397/
Abstract

Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a key keratinocyte mechanotransducer. Keratinocyte expression of PIEZO1 is critical for normal sensory afferent firing and behavioral responses to mechanical stimuli in mice.

摘要

表皮角质形成细胞通过检测和编码触觉信息来传递触觉感觉，从而介导触觉感受。然而，能够使角质形成细胞对机械刺激产生反应的特定机械感受器仍不清楚。在这里，我们发现机械门控离子通道 PIEZO1 是角质形成细胞的关键机械感受器。角质形成细胞中 PIEZO1 的表达对于正常的感觉传入放电和小鼠对机械刺激的行为反应至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06e/9512397/4df8d4175d2d/elife-65987-fig5-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06e/9512397/e97dae6e51e9/elife-65987-fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06e/9512397/aaff497e76b0/elife-65987-fig3-figsupp1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06e/9512397/84a07ce13d48/elife-65987-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06e/9512397/4df8d4175d2d/elife-65987-fig5-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06e/9512397/e97dae6e51e9/elife-65987-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06e/9512397/4c5330413bde/elife-65987-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06e/9512397/6abbdd99982a/elife-65987-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06e/9512397/a44be37efd24/elife-65987-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06e/9512397/aaff497e76b0/elife-65987-fig3-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06e/9512397/f055b93a8e06/elife-65987-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06e/9512397/84a07ce13d48/elife-65987-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f06e/9512397/4df8d4175d2d/elife-65987-fig5-figsupp1.jpg

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