Georgetown Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C., United States of America.
PLoS One. 2022 Sep 2;17(9):e0273911. doi: 10.1371/journal.pone.0273911. eCollection 2022.
Fiber intake may be associated with lower risk of metabolic syndrome (MetS) but data from metabolically unhealthy African American women is sparse. We examined the association of dietary fiber intake and MetS among postmenopausal African American women with obesity. Baseline cross-sectional data from the Focused Intervention on Exercise to Reduce CancEr (FIERCE) trial of 213 women (mean age 58.3 years) were used. Dietary intake was assessed by Food Frequency Questionnaires (FFQs). Multivariate linear and logistic regressions were performed to estimate associations of MetS with fiber intake and adherence to dietary fiber intake guidelines, respectively. Mean daily fiber intake was (10.33 g/1000kcal) in women with impaired metabolic health. We observed an inverse association of total fiber intake with MetS. One unit increase in energy-adjusted fiber intake was associated with a 0.10 unit decrease in the MetS z-score (p = 0.02). Similar results were obtained for both soluble and insoluble fiber. In multivariate-adjusted analyses, participants not adherent to fiber intake recommendations were more likely to have MetS as compared to those reporting intakes in the recommended range (adjusted odds ratio 4.24, 95% CI: 1.75, 10.30). Of the MetS components, high fasting glucose and high triglycerides were all associated with lower intake of fiber. Study participants who consumed a higher amount of fiber had a better overall metabolic profile and were less likely to have MetS in our cross-sectional analysis of postmenopausal African American women with obesity and unhealthy metabolic profiles.
膳食纤维的摄入量可能与代谢综合征（MetS）的风险降低有关，但关于代谢不健康的非裔美国女性的数据却很少。我们研究了膳食纤维摄入量与肥胖绝经后非裔美国女性代谢综合征之间的关系。本研究使用了聚焦锻炼干预以降低癌症（FIERCE）试验 213 名女性（平均年龄 58.3 岁）的基线横断面数据。膳食纤维的摄入量通过食物频率问卷（FFQs）进行评估。多元线性和逻辑回归分别用于估计代谢综合征与纤维摄入量以及遵循膳食纤维摄入量指南之间的相关性。代谢不健康女性的平均每日膳食纤维摄入量为（10.33 g/1000kcal）。我们观察到总纤维摄入量与代谢综合征呈负相关。能量调整后的纤维摄入量每增加一个单位，代谢综合征 z 评分就会降低 0.10 个单位（p = 0.02）。可溶性纤维和不溶性纤维都得到了类似的结果。在多变量调整分析中，与报告摄入量在推荐范围内的参与者相比，不遵守纤维摄入量建议的参与者更有可能患有代谢综合征（调整后的优势比 4.24，95%CI：1.75，10.30）。在代谢综合征的各个组成部分中，高空腹血糖和高三酰甘油均与较低的纤维摄入量相关。在对肥胖和代谢不健康的绝经后非裔美国女性进行的横断面分析中，我们发现，摄入更多纤维的研究参与者具有更好的整体代谢特征，且患有代谢综合征的可能性更小。
