Noyes R, Clarkson C, Crowe R R, Yates W R, McChesney C M
Am J Psychiatry. 1987 Aug;144(8):1019-24. doi: 10.1176/ajp.144.8.1019.
The frequency of generalized anxiety disorder was higher among first-degree relatives of probands with generalized anxiety (N = 20) than among the relatives of control subjects (N = 20), but it was not higher among relatives of probands with panic disorder (N = 40) or agoraphobia (N = 40). Also, the frequency of panic disorder was higher among relatives of probands with panic disorder than among control relatives but was not higher among relatives of generalized anxiety probands. Relatives of probands with generalized anxiety who had the same disorder had a mild, stress-related illness. The results confirm the separation between generalized anxiety disorder and panic disorder but challenge the distinction between generalized anxiety and adjustment disorders.
广泛性焦虑症患者（N = 20）的一级亲属中广泛性焦虑症的发病率高于对照受试者（N = 20）的亲属，但惊恐障碍患者（N = 40）或场所恐惧症患者（N = 40）的亲属中该发病率并未更高。同样，惊恐障碍患者的亲属中惊恐障碍的发病率高于对照亲属，但广泛性焦虑症患者的亲属中该发病率并未更高。患有相同疾病的广泛性焦虑症患者的亲属患有轻度的、与压力相关的疾病。结果证实了广泛性焦虑症和惊恐障碍之间的区别，但对广泛性焦虑症和适应障碍之间的区分提出了挑战。
