吞噬细胞膜刺激对抗生素摄取及细胞内杀菌活性的影响。
Effect of phagocyte membrane stimulation on antibiotic uptake and intracellular bactericidal activity.
作者信息
Steinberg T H, Hand W L
出版信息
Antimicrob Agents Chemother. 1987 Apr;31(4):660-2. doi: 10.1128/AAC.31.4.660.
Abstract
Phagocytosis stimulated a substantial increase in clindamycin uptake and a smaller increase in rifampin accumulation by polymorphonuclear leukocytes. The effect of this increased antibiotic uptake on intraphagocytic bactericidal activity was evaluated. Although zymosan stimulated antibiotic uptake by polymorphonuclear leukocytes, neither zymosan nor formyl-methionyl-leucyl-phenylalanine enhanced the ability of clindamycin or rifampin to kill ingested staphylococci. Properties other than antibiotic uptake are important in determining intraphagocytic bactericidal activity.
摘要
吞噬作用刺激多形核白细胞对克林霉素的摄取大幅增加，对利福平的蓄积增加幅度较小。评估了这种抗生素摄取增加对吞噬细胞内杀菌活性的影响。虽然酵母聚糖刺激多形核白细胞摄取抗生素，但酵母聚糖和甲酰甲硫氨酰亮氨酰苯丙氨酸均未增强克林霉素或利福平杀灭摄入葡萄球菌的能力。除抗生素摄取外的其他特性在决定吞噬细胞内杀菌活性方面很重要。
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