Mahmoudzadeh Elaheh, Nazemiyeh Hossein, Hamedeyazdan Sanaz
Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Iran J Pharm Res. 2022 Apr 5;21(1):e123949. doi: 10.5812/ijpr.123949. eCollection 2022 Dec.
The genus has been mainly used in traditional medicine, containing its anti-inflammatory activity. spp.'s active components, such as allantoin, polyphenols, flavonoids, and alkaloids, can act on several intentions in the signaling pathway, constrain pro-inflammatory enzymes, reducing the construction of inflammatory chemokine's and cytokines, and decreasing oxidative stress, which afterward suppresses inflammation procedures. Preclinical and clinical trials have reported the prevailing anti-inflammatory effect of several species. This review presents an overview of the anti-inflammatory activities of different products and bioactive constituents in this genus. The papers with the English language were gathered from 2000 to 2021. This review may provide a scientific base for establishing innovative and alternative techniques for isolating a single individual from this genus to attenuate inflammatory disorders. The genus is waiting for researchers to develop safe and effective anti-inflammatory agents for additional investigation of other different mechanisms of action.
该属主要用于传统医学，具有抗炎活性。该属植物的活性成分，如尿囊素、多酚、黄酮类化合物和生物碱，可作用于信号通路中的多个靶点，抑制促炎酶，减少炎症趋化因子和细胞因子的生成，并降低氧化应激，进而抑制炎症过程。临床前和临床试验已报道了该属几种植物普遍存在的抗炎作用。本综述概述了该属不同产品和生物活性成分的抗炎活性。收集了2000年至2021年的英文文献。本综述可为建立从该属中分离单一成分以减轻炎症性疾病的创新和替代技术提供科学依据。该属植物正等待研究人员开发安全有效的抗炎药物，以进一步研究其他不同的作用机制。
