Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Clinical Nuclear Medicine Center, Tongji University School of Medicine, Shanghai, China.
Front Endocrinol (Lausanne). 2022 Aug 18;13:943408. doi: 10.3389/fendo.2022.943408. eCollection 2022.
Emerging studies have provided a preliminary understanding of the thyroid-gut axis, indicating that intestinal microbiota and its metabolites may act directly or indirectly on the thyroid by influencing intestinal microelements uptake, iodothyronine conversion and storage, and immune regulation, providing new insights into the pathogenesis of thyroid disorders and clinical management strategies. However, the research on gut microbiota and thyroid has only presented the tip of the iceberg. More robust clinical data and basic experiments are still required to elucidate the specific relationships and mechanisms in the future. Here we will characterize the associations between the microbiota and thyroid diseases to evaluate their potential implications in the pathophysiology and open up scientific avenues for future precision studies of the thyroid-gut axis.
新兴研究提供了对甲状腺-肠道轴的初步理解，表明肠道微生物群及其代谢产物可能通过影响肠道微量元素摄取、甲状腺素转化和储存以及免疫调节，直接或间接地对甲状腺产生作用，为甲状腺疾病的发病机制和临床管理策略提供了新的见解。然而，关于肠道微生物群和甲状腺的研究只是冰山一角。未来仍需要更多强有力的临床数据和基础实验来阐明具体的关系和机制。在这里，我们将描述微生物群与甲状腺疾病之间的关联，以评估它们在病理生理学中的潜在意义，并为未来甲状腺-肠道轴的精确研究开辟科学途径。
