ω-3 脂肪酸补充剂对炎症生物标志物的疗效：伞式荟萃分析。
Efficacy of the omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis.
机构信息
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Int Immunopharmacol. 2022 Oct;111:109104. doi: 10.1016/j.intimp.2022.109104. Epub 2022 Jul 30.
BACKGROUND
Existing meta-analyses on omega-3 polyunsaturated fatty acids and their anti-inflammatory effects have reported uncertain findings. The current umbrella meta-analysis aimed to assess the findings of multiple meta-analyses on the efficacy of n-3 PUFAs on inflammatory biomarkers in adults with different health conditions.
METHODS
Using suitable keywords, articles published until December 2021 were searched in PubMed/Medline, Web of Science, Scopus, EMBASE, and Google Scholar. Meta-analyses investigating the impact of supplementation of n-3 PUFAs on inflammatory biomarkers in adults were included. We performed this meta-analysis using a random-effects model.
RESULTS
Overall, 32 meta-analyses were qualified in this umbrella meta-analysis. Our findings demonstrated that the n-3 PUFA supplementation significantly reduced serum C-reactive protein (CRP) (ES = -0.40; 95 % CI: -0.56, -0.24, p < 0.001; I = 89.5 %, p < 0.001), Tumour necrosis factor α (TNFα) (ES = -0.23; 95 % CI: -0.37, -0.08, p = 0.002; I = 60.1 %, p < 0.001), and interleukin 6 (IL-6) concentrations (ES = -0.22; 95 % CI: -0.39, -0.05, p = 0.010; I = 66.2 %, p < 0.001).
CONCLUSION
The current umbrella meta-analysis found that supplementation of n-3 PUFAs in adults can improve CRP, TNF-α, and IL-6 concentrations under various health conditions. n-3 PUFAs can be recommended as adjuvant anti-inflammatory agents.
背景
现有的关于ω-3 多不饱和脂肪酸及其抗炎作用的荟萃分析报告结果并不确定。本伞式荟萃分析旨在评估针对不同健康状况的成年人中 n-3 多不饱和脂肪酸对炎症生物标志物疗效的多项荟萃分析的结果。
方法
使用合适的关键词，在 PubMed/Medline、Web of Science、Scopus、EMBASE 和 Google Scholar 中搜索截至 2021 年 12 月发表的文章。纳入研究 n-3 多不饱和脂肪酸补充对成年人炎症生物标志物影响的荟萃分析。我们使用随机效应模型进行了这项荟萃分析。
结果
总体而言，本伞式荟萃分析中有 32 项荟萃分析符合条件。我们的研究结果表明，n-3 多不饱和脂肪酸补充显著降低了血清 C 反应蛋白（CRP）（ES=-0.40；95%CI：-0.56，-0.24，p<0.001；I=89.5%，p<0.001）、肿瘤坏死因子-α（TNFα）（ES=-0.23；95%CI：-0.37，-0.08，p=0.002；I=60.1%，p<0.001）和白细胞介素 6（IL-6）浓度（ES=-0.22；95%CI：-0.39，-0.05，p=0.010；I=66.2%，p<0.001）。
结论
本伞式荟萃分析发现，在各种健康状况下，成年人补充 n-3 多不饱和脂肪酸可以改善 CRP、TNF-α 和 IL-6 浓度。n-3 多不饱和脂肪酸可以作为辅助抗炎药物推荐。
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