原发性硬化性胆管炎：放射科医师的综述。
Primary sclerosing cholangitis: review for radiologists.
机构信息
Department of Radiology, University of Pennsylvania Health System, 1 Silverstein, 3400 Spruce Street, Philadelphia, PA, USA.
Radiology and Medical Imaging, University of Virginia Health, 1215 Lee Street, Charlottesville, VA, USA.
出版信息
Abdom Radiol (NY). 2023 Jan;48(1):136-150. doi: 10.1007/s00261-022-03655-6. Epub 2022 Sep 5.
Abstract
Primary sclerosing cholangitis is a rare chronic inflammatory disease affecting the bile ducts, which can eventually result in bile duct strictures, cholestasis and cirrhosis. Patients are often asymptomatic but may present with clinical features of cholestasis. Imaging plays an important role in the diagnosis and management. This review covers the pathophysiology, clinical features, imaging findings as well as methods of surveillance and post-transplant appearance.
摘要
原发性硬化性胆管炎是一种罕见的慢性炎症性疾病，影响胆管，最终可导致胆管狭窄、胆汁淤积和肝硬化。患者通常无症状，但可能出现胆汁淤积的临床特征。影像学在诊断和治疗中起重要作用。本文综述了其病理生理学、临床特征、影像学表现以及监测和移植后表现的方法。
相似文献
1
Primary sclerosing cholangitis: review for radiologists.原发性硬化性胆管炎：放射科医师的综述。
Abdom Radiol (NY). 2023 Jan;48(1):136-150. doi: 10.1007/s00261-022-03655-6. Epub 2022 Sep 5.
2
Imaging Features of Primary Sclerosing Cholangitis: From Diagnosis to Liver Transplant Follow-up.原发性硬化性胆管炎的影像学特征：从诊断到肝移植随访。
Radiographics. 2019 Nov-Dec;39(7):1938-1964. doi: 10.1148/rg.2019180213. Epub 2019 Oct 18.
3
Pathophysiology and Diseases of the Proximal Pathways of the Biliary System.胆道系统近端通路的病理生理学与疾病
Arch Pathol Lab Med. 2015 Jul;139(7):858-66. doi: 10.5858/arpa.2014-0229-RA.
4
Sclerosing Cholangitis: Clinicopathologic Features, Imaging Spectrum, and Systemic Approach to Differential Diagnosis.硬化性胆管炎：临床病理特征、影像学表现及鉴别诊断的系统方法
Korean J Radiol. 2016 Jan-Feb;17(1):25-38. doi: 10.3348/kjr.2016.17.1.25. Epub 2016 Jan 6.
5
[Eosinophilic cholangitis from almost normal appearance to the bile duct sclerosis similar to primary sclerosing cholangitis].[从几乎正常外观到类似于原发性硬化性胆管炎的胆管硬化的嗜酸性胆管炎]
Nihon Shokakibyo Gakkai Zasshi. 2013 Feb;110(2):271-81.
6
A Patient with Primary Sclerosing Cholangitis and Diffuse Biliary Dilation.一名原发性硬化性胆管炎伴弥漫性胆管扩张患者。
Gastroenterology. 2021 Feb;160(3):e17-e18. doi: 10.1053/j.gastro.2020.06.053. Epub 2020 Jun 27.
7
Bile duct wall thickness measured by intraductal US in patients who have not undergone previous biliary drainage.在未接受过先前胆道引流的患者中，通过导管内超声测量胆管壁厚度。
Gastrointest Endosc. 1999 Feb;49(2):199-203. doi: 10.1016/s0016-5107(99)70486-4.
8
A case of primary intrahepatic sclerosing cholangitis (PISC) complicated with atypical biliary epithelial proliferation.一例原发性肝内硬化性胆管炎（PISC）合并非典型胆管上皮细胞增生。
Intern Med. 1992 Jan;31(1):114-21. doi: 10.2169/internalmedicine.31.114.
9
Reporting standards for primary sclerosing cholangitis using MRI and MR cholangiopancreatography: guidelines from MR Working Group of the International Primary Sclerosing Cholangitis Study Group.原发性硬化性胆管炎的 MRI 和 MR 胆胰管成像报告标准：国际原发性硬化性胆管炎研究组磁共振工作组指南。
Eur Radiol. 2022 Feb;32(2):923-937. doi: 10.1007/s00330-021-08147-7. Epub 2021 Aug 6.
10
Chronic cholestatic liver diseases: clues from histopathology for pathogenesis.慢性胆汁淤积性肝病：从组织病理学角度探讨其发病机制
Mol Aspects Med. 2014 Jun;37:35-56. doi: 10.1016/j.mam.2013.10.001. Epub 2013 Oct 17.
引用本文的文献
1
Exploring the Role of MRCP+ for Enhancing Detection of High-Grade Strictures in Primary Sclerosing Cholangitis.探索磁共振胰胆管造影（MRCP）+在增强原发性硬化性胆管炎中高级别狭窄检测方面的作用。
J Clin Med. 2025 Aug 6;14(15):5530. doi: 10.3390/jcm14155530.
2
Primary sclerosing cholangitis: Is qualitative and quantitative 3 T MR imaging useful for the evaluation of disease severity?原发性硬化性胆管炎：3T磁共振成像的定性和定量分析对疾病严重程度评估是否有用？
Eur J Radiol Open. 2024 Aug 12;13:100595. doi: 10.1016/j.ejro.2024.100595. eCollection 2024 Dec.
3
Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications.胆汁纤维化是肝胆疾病中一个重要但被忽视的病理特征：从分子机制到临床意义。
Med Rev (2021). 2024 Jul 1;4(4):326-365. doi: 10.1515/mr-2024-0029. eCollection 2024 Aug.
4
Primary Sclerosing Cholangitis Associated With Ulcerative Colitis Coexisting With Cholangiocarcinoma: A Case Report.原发性硬化性胆管炎合并溃疡性结肠炎并存胆管癌：一例报告
Cureus. 2024 Jun 17;16(6):e62531. doi: 10.7759/cureus.62531. eCollection 2024 Jun.
5
Acquired ductopenia: an insight into imaging findings.获得性胆管减少症：影像学表现的深入探讨
Abdom Radiol (NY). 2025 Jan;50(1):152-168. doi: 10.1007/s00261-024-04462-x. Epub 2024 Jul 2.
6
Isolated hepatic sarcoidosis: A case series.孤立性肝结节病：病例系列
Can Liver J. 2024 May 8;7(2):316-321. doi: 10.3138/canlivj-2023-0030. eCollection 2024 May.
7
Serum Galectin-3 as a Non-Invasive Marker for Primary Sclerosing Cholangitis.血清半乳糖凝集素-3 作为原发性硬化性胆管炎的非侵入性标志物。
Int J Mol Sci. 2024 Apr 27;25(9):4765. doi: 10.3390/ijms25094765.
本文引用的文献
1
Management of Incidentally Detected Gallbladder Polyps: Society of Radiologists in Ultrasound Consensus Conference Recommendations.偶然发现的胆囊息肉的处理：超声放射学家学会共识会议推荐意见。
Radiology. 2022 Nov;305(2):277-289. doi: 10.1148/radiol.213079. Epub 2022 Jul 5.
2
Secondary sclerosing cholangitis: mimics of primary sclerosing cholangitis.继发性硬化性胆管炎：原发性硬化性胆管炎的模拟疾病。
Abdom Radiol (NY). 2023 Jan;48(1):151-165. doi: 10.1007/s00261-022-03551-z. Epub 2022 May 18.
3
Imaging of benign biliary pathologies.良性胆道病变的影像学检查
Abdom Radiol (NY). 2023 Jan;48(1):106-126. doi: 10.1007/s00261-022-03440-5. Epub 2022 Feb 24.
4
Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE.胆囊息肉的管理和随访：ESGAR、EAES、EFISDS 和 ESGE 联合更新指南
Eur Radiol. 2022 May;32(5):3358-3368. doi: 10.1007/s00330-021-08384-w. Epub 2021 Dec 17.
5
Epidemiology, Natural History, and Outcomes of Primary Sclerosing Cholangitis: A Systematic Review of Population-based Studies.原发性硬化性胆管炎的流行病学、自然史和结局：基于人群的研究系统评价。
Clin Gastroenterol Hepatol. 2022 Aug;20(8):1687-1700.e4. doi: 10.1016/j.cgh.2021.08.039. Epub 2021 Aug 30.
6
Reporting standards for primary sclerosing cholangitis using MRI and MR cholangiopancreatography: guidelines from MR Working Group of the International Primary Sclerosing Cholangitis Study Group.原发性硬化性胆管炎的 MRI 和 MR 胆胰管成像报告标准：国际原发性硬化性胆管炎研究组磁共振工作组指南。
Eur Radiol. 2022 Feb;32(2):923-937. doi: 10.1007/s00330-021-08147-7. Epub 2021 Aug 6.
7
Global incidence, prevalence and features of primary sclerosing cholangitis: A systematic review and meta-analysis.原发性硬化性胆管炎的全球发病率、患病率及特征：系统评价和荟萃分析。
Liver Int. 2021 Oct;41(10):2418-2426. doi: 10.1111/liv.15007. Epub 2021 Jul 19.
8
EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis - 2021 update.EASL 临床实践指南：非侵入性检测评估肝脏疾病严重程度和预后——2021 更新版。
J Hepatol. 2021 Sep;75(3):659-689. doi: 10.1016/j.jhep.2021.05.025. Epub 2021 Jun 21.
9
Early Cholangiocarcinoma Detection With Magnetic Resonance Imaging Versus Ultrasound in Primary Sclerosing Cholangitis.原发性硬化性胆管炎的磁共振成像与超声早期胆管癌检测。
Hepatology. 2021 May;73(5):1868-1881. doi: 10.1002/hep.31575. Epub 2021 Apr 19.
10
Clinical features and MRI progression of small duct primary sclerosing cholangitis (PSC).小胆管原发性硬化性胆管炎（PSC）的临床特征和 MRI 进展。
Eur J Radiol. 2020 Aug;129:109101. doi: 10.1016/j.ejrad.2020.109101. Epub 2020 Jun 1.
Zotero 插件