Zhang Lei, Chu Mengge, Ji Cailing, Tan Jie, Yuan Quan
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082 China.
Nano Res. 2023;16(3):3895-3912. doi: 10.1007/s12274-022-4793-5. Epub 2022 Aug 31.
As a carrier of genetic information, DNA is a versatile module for fabricating nanostructures and nanodevices. Functional molecules could be integrated into DNA by precise base complementary pairing, greatly expanding the functions of DNA nanomaterials. These functions endow DNA nanomaterials with great potential in the application of biomedical field. In recent years, functional DNA nanomaterials have been rapidly investigated and perfected. There have been reviews that classified DNA nanomaterials from the perspective of functions, while this review primarily focuses on the preparation methods of functional DNA nanomaterials. This review comprehensively introduces the preparation methods of DNA nanomaterials with functions such as molecular recognition, nanozyme catalysis, drug delivery, and biomedical material templates. Then, the latest application progress of functional DNA nanomaterials is systematically reviewed. Finally, current challenges and future prospects for functional DNA nanomaterials are discussed.
作为遗传信息的载体，DNA是一种用于制造纳米结构和纳米器件的多功能模块。功能分子可以通过精确的碱基互补配对整合到DNA中，极大地扩展了DNA纳米材料的功能。这些功能赋予了DNA纳米材料在生物医学领域应用的巨大潜力。近年来，功能DNA纳米材料得到了迅速的研究和完善。已有综述从功能角度对DNA纳米材料进行了分类，而本综述主要关注功能DNA纳米材料的制备方法。本综述全面介绍了具有分子识别、纳米酶催化、药物递送和生物医学材料模板等功能的DNA纳米材料的制备方法。然后，系统地综述了功能DNA纳米材料的最新应用进展。最后，讨论了功能DNA纳米材料当前面临的挑战和未来前景。
