Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.
J Am Chem Soc. 2022 Sep 21;144(37):16684-16697. doi: 10.1021/jacs.2c07688. Epub 2022 Sep 7.
Appetite for reactions involving PH has grown in the past few years. This in part is due to the ability to generate PH cleanly and safely via digestion of cheap metal phosphides with acids, thus avoiding pressurized cylinders and specialized equipment. In this perspective we highlight current trends in forming new P-C/P-OC bonds with PH and discuss the challenges involved with selectivity and product separation encumbering these reactions. We highlight the reactivity of PH with main group reagents, building on the early pioneering work with transition metal complexes and PH. Additionally, we highlight the recent renewal of interest in alkali metal sources of HP which are proving to be useful synthons for chemistry across the periodic table. Such MPH sources are being used to generate the desired products in a more controlled fashion and are allowing access to unexplored phosphorus-containing species.
近年来，人们对涉及 PH 的反应产生了浓厚的兴趣。这在一定程度上是由于能够通过酸消化廉价金属膦化物来安全地清洁地产生 PH，从而避免使用加压钢瓶和专用设备。从这个角度出发，我们强调了通过 PH 形成新的 P-C/P-OC 键的当前趋势，并讨论了这些反应中选择性和产物分离所带来的挑战。我们强调了 PH 与主族试剂的反应性，这是基于早期与过渡金属配合物和 PH 的开创性工作。此外，我们还强调了人们对碱金属 HP 源的兴趣最近重新燃起，这些源被证明是整个元素周期表化学中有用的合成子。这些 MPH 源被用于以更可控的方式生成所需的产物，并允许人们接触到未探索过的含磷物种。
