Douzon C, Kanmangne F M, Serne H, Labarre D, Jozefowicz M
Biomaterials. 1987 May;8(3):190-4. doi: 10.1016/0142-9612(87)90062-7.
It has been demonstrated previously that polystyrene sulphonate possesses anticoagulant properties and that the binding of some amino acids could enhance the heparin-like properties of such resins. These properties depend on the surface density of the active groups, the nature and binding of the group and on the net change borne by the polymer. In this paper, we describe the preparation of copolystyrene (sulphonate-dicarboxylic amino acid sulphamide) resins. By measuring their antithrombotic-surface-activity, we demonstrate that the activity developed by each carboxyl group is at least roughly the same as the activity of one sulphonate group, except in the case of aspartic acid sulphamide resin for which a cooperative effect is shown. The anticoagulant properties of resins bearing phosphonate or monocarboxylic amino acid sulphamides are also examined.
先前已经证明聚苯乙烯磺酸盐具有抗凝血特性，并且某些氨基酸的结合可以增强此类树脂的类肝素特性。这些特性取决于活性基团的表面密度、基团的性质和结合方式以及聚合物所带的净电荷。在本文中，我们描述了共聚聚苯乙烯（磺酸盐 - 二羧酸氨基酸磺酰胺）树脂的制备。通过测量它们的抗血栓表面活性，我们证明，除了显示出协同效应的天冬氨酸磺酰胺树脂外，每个羧基产生的活性至少大致与一个磺酸根基团的活性相同。还研究了带有膦酸酯或单羧酸氨基酸磺酰胺的树脂的抗凝血特性。
