Wang Xinhui, Ma Yuan, Niu Xingtang, Su Ting, Huang Xiaoqi, Lu Feng, Chang Qiang
Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Front Bioeng Biotechnol. 2022 Aug 22;10:930551. doi: 10.3389/fbioe.2022.930551. eCollection 2022.
Current wound dressing based on hydrogel offers a promising way to accelerate the healing process, yet great challenges remain in the development of a highly integrated and efficient platform with the combination of therapeutic biomolecules and stem cells. Herein, a natural hydrogel wound dressing from egg white can be conveniently obtained by feasible physical crosslinking, the prepared hydrogel dressing features interconnected microporous channels, direct 3D printing, cytocompatibility, and intrinsic biomolecules to advance cell behavior. The 3D printed egg white hydrogels promote the adhesion and proliferation of adipose-derived stem cells (ASCs) without obvious cytotoxicity. In addition, this integrated hydrogel platform accompanied with adipose-derived stem cells accelerates wound healing through the enhancement of fibroblast proliferation, angiogenesis, and collagen rearrangement in the wound bed. The egg white hydrogel provides an effective wound caring product possessing low cost, easy availability along with ready manufacturing, and advanced therapeutic effect, which may be extended for the management of chronic or other complicated wounds.
基于水凝胶的当前伤口敷料为加速愈合过程提供了一种很有前景的方法，然而，在开发一个将治疗性生物分子和干细胞相结合的高度集成且高效的平台方面，仍然存在巨大挑战。在此，通过可行的物理交联可以方便地获得一种源自蛋清的天然水凝胶伤口敷料，所制备的水凝胶敷料具有相互连接的微孔通道、直接3D打印、细胞相容性以及促进细胞行为的内在生物分子。3D打印的蛋清水凝胶可促进脂肪来源干细胞（ASC）的黏附和增殖，且无明显细胞毒性。此外，这个与脂肪来源干细胞相结合的集成水凝胶平台通过增强伤口床中成纤维细胞的增殖、血管生成和胶原蛋白重排来加速伤口愈合。蛋清水凝胶提供了一种有效的伤口护理产品，具有低成本、易于获取以及易于制造的特点，并且具有先进的治疗效果，这可能会扩展到慢性或其他复杂伤口的管理中。
