Nordgaard Julie, Berge Jonas, Rasmussen Andreas Rosén, Sandsten Karl Erik, Zandersen Maja, Parnas Josef
Mental Health Center Amager, Gammel Kongevej 33, 1610 Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
Schizophr Bull. 2023 Jan 3;49(1):144-150. doi: 10.1093/schbul/sbac123.
The idea that a disorder of the basic self is a central feature in schizophrenia has recently been corroborated in a meta-analysis and a systematic review. Manifestations of the self-disorder can be systematically explored with the Examination of Anomalous Self-Experience (EASE). In this study, we examined the factorial structure of EASE, and diagnostic efficacy of EASE. We hypothesized that EASE will have a monofactorial structure as an instability of the basic self will result in multiple deformations of self-experience which would be meaningfully interrelated as aspects of a unifying Gestalt.
EASE data for 226 patients suffering from various mental disorders were analyzed under a confirmatory factor analysis framework (CFA). Area under the receiver operating characteristic curve (AUC) was calculated for the total EASE sums, and sensitivity and specificity values for prediction of schizophrenia spectrum disorders based on different cut-offs were obtained.
Fit indices for the CFA model: RMSEA = 0.036, SRMR = 0.100, CFI = 0.983, TLI = 0.981. The AUC value was 0.946 (95% confidence interval: 0.919-0.974). Sensitivity as well as specificity for schizophrenia spectrum disorders were high.
Our results lend support for EASE exhibiting a monofactorial structure and the notion of self-disorders as a central phenotypic feature of schizophrenia spectrum disorders.
基础自我障碍是精神分裂症的核心特征这一观点最近在一项荟萃分析和系统评价中得到了证实。自我障碍的表现可以通过异常自我体验检查（EASE）进行系统探究。在本研究中，我们考察了EASE的因子结构以及EASE的诊断效能。我们假设EASE将具有单因素结构，因为基础自我的不稳定会导致自我体验的多种变形，这些变形作为一个统一格式塔的各个方面将具有有意义的相互关系。
在验证性因子分析框架（CFA）下分析了226名患有各种精神障碍患者的EASE数据。计算了EASE总分的受试者工作特征曲线下面积（AUC），并获得了基于不同临界值预测精神分裂症谱系障碍的敏感性和特异性值。
CFA模型的拟合指数：RMSEA = 0.036，SRMR = 0.100，CFI = 0.983，TLI = 0.981。AUC值为0.946（95%置信区间：0.919 - 0.974）。精神分裂症谱系障碍的敏感性和特异性都很高。
我们的结果支持EASE具有单因素结构以及自我障碍是精神分裂症谱系障碍的核心表型特征这一观点。
