Nagy E, Berczi I
Acta Endocrinol (Copenh). 1978 Nov;89(3):530-7. doi: 10.1530/acta.0.0890530.
The response of hypophysectomized, sham-operated and non-operated female Fischer 344 and Wistar-Furth rats was compared to various antigenic stimuli. Antibody production against sheep red blood cells, skin response to dinitrochlorobenzene and the development of adjuvant arthritis after treatment with Freund's complete adjuvant were all markedly suppressed in hypophysectomized animals. Sham-operated rats responded as well as did non-operated controls. Skin graft survival was also prolonged in hypophysectomized rats when compared to controls. These results indicate that the pituitary gland plays an important role in immune reactions.
将切除垂体、假手术和未手术的雌性Fischer 344大鼠及Wistar-Furth大鼠对各种抗原刺激的反应进行了比较。切除垂体的动物针对绵羊红细胞产生抗体的能力、对二硝基氯苯的皮肤反应以及在用弗氏完全佐剂处理后佐剂性关节炎的发展均受到显著抑制。假手术大鼠的反应与未手术的对照大鼠相同。与对照相比，切除垂体的大鼠皮肤移植存活时间也延长了。这些结果表明垂体在免疫反应中起重要作用。
