Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Biomed Pharmacother. 2022 Sep;153:113480. doi: 10.1016/j.biopha.2022.113480. Epub 2022 Jul 27.
Cancer is one of the primary causes of death worldwide, and its morbidity and mortality rates are increasing rapidly. However, standard treatment modalities (surgery, radiotherapy, chemotherapy, and immunotherapy) often fail to achieve a satisfactory therapeutic effect. Extracellular vesicles (EVs) are natural nano-sized lipid bilayer vesicles secreted from cells. Owing to their advantages of low toxicity, high biocompatibility, low immunogenicity, and inherent targeting, EVs can be exploited as drug delivery vectors for cancer treatment. In this review, we summarize the research progress of EV-based drug delivery systems in cancer treatment by focusing on four aspects: sources, cargo types, cargo loading methods and modification strategies. Finally, current challenges and future perspectives are discussed.
癌症是全球主要死亡原因之一，其发病率和死亡率正在迅速上升。然而，标准治疗方法（手术、放疗、化疗和免疫疗法）往往无法达到令人满意的治疗效果。细胞外囊泡（EVs）是细胞分泌的天然纳米级脂质双层囊泡。由于其毒性低、生物相容性高、免疫原性低和固有靶向性，EVs 可以被开发为癌症治疗的药物递送载体。在本文中，我们通过关注四个方面：来源、货物类型、货物装载方法和修饰策略，总结了基于 EV 的药物递送系统在癌症治疗中的研究进展。最后，讨论了当前的挑战和未来的展望。
