免疫治疗时代突变抗原的鉴定与临床应用
The Identification and Clinical Applications of Mutated Antigens in the Era of Immunotherapy.
作者信息
Kye Yae, Nagineni Lokesh, Gadad Shrikanth, Ramirez Fabiola, Riva Hannah, Fernandez Lorena, Samaniego Michelle, Holland Nathan, Yeh Rose, Takigawa Kei, Dhandayuthapani Subramanian, Chacon Jessica
机构信息
Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.
L. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.
出版信息
Cancers (Basel). 2022 Aug 31;14(17):4255. doi: 10.3390/cancers14174255.
The era of personalized cancer therapy is here. Advances in the field of immunotherapy have paved the way for the development of individualized neoantigen-based therapies that can translate into favorable treatment outcomes and fewer side effects for patients. Addressing challenges related to the identification, access, and clinical application of neoantigens is critical to accelerating the development of individualized immunotherapy for cancer patients.
个性化癌症治疗的时代已经到来。免疫治疗领域的进展为基于个性化新抗原的疗法的发展铺平了道路，这类疗法能够为患者带来良好的治疗效果并减少副作用。应对与新抗原的识别、获取及临床应用相关的挑战，对于加速为癌症患者开发个性化免疫疗法至关重要。
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