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用于人体植入物的纳米多孔不锈钢材料——合成工艺综述

Nanoporous Stainless Steel Materials for Body Implants-Review of Synthesizing Procedures.

作者信息

Benčina Metka, Junkar Ita, Vesel Alenka, Mozetič Miran, Iglič Aleš

机构信息

Department of Surface Engineering, Jožef Stefan Institute, Jamova Cesta 39, 1000 Ljubljana, Slovenia.

Laboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana, 1000 Ljubljana, Slovenia.

出版信息

Nanomaterials (Basel). 2022 Aug 25;12(17):2924. doi: 10.3390/nano12172924.

Abstract

Despite the inadequate biocompatibility, medical-grade stainless steel materials have been used as body implants for decades. The desired biological response of surfaces to specific applications in the body is a highly challenging task, and usually not all the requirements of a biomaterial can be achieved. In recent years, nanostructured surfaces have shown intriguing results as cell selectivity can be achieved by specific surface nanofeatures. Nanoporous structures can be fabricated by anodic oxidation, which has been widely studied for titanium and its alloys, while no systematic studies are so far available for stainless steel (SS) materials. This paper reviews the current state of the art in the anodisation of SS; correlations between the parameters of anodic oxidation and the surface morphology are drawn. The results reported by various authors are scattered because of a variety of experimental configurations. A linear correlation between the pores' diameter anodisation voltage was deduced, while no correlation with other processing parameters was found obvious. The analyses of available data indicated a lack of systematic experiments, which are recommended to understand the kinetics of pore formation and develop techniques for optimal biocompatibility of stainless steel.

摘要

尽管医用级不锈钢材料的生物相容性不足,但几十年来一直被用作人体植入物。使材料表面对身体特定应用产生理想的生物反应是一项极具挑战性的任务,而且生物材料的所有要求通常无法全部实现。近年来,纳米结构表面已显示出有趣的结果,因为可以通过特定的表面纳米特征实现细胞选择性。纳米多孔结构可通过阳极氧化制备,阳极氧化已在钛及其合金方面得到广泛研究,而目前尚未对不锈钢材料进行系统研究。本文综述了不锈钢阳极氧化的当前技术水平;得出了阳极氧化参数与表面形态之间的相关性。由于各种实验配置,不同作者报告的结果较为分散。推导了孔径与阳极氧化电压之间的线性相关性,而未发现与其他加工参数有明显相关性。对现有数据的分析表明缺乏系统实验,建议进行此类实验以了解孔形成的动力学并开发实现不锈钢最佳生物相容性的技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7802/9457931/7d39fc3e60ca/nanomaterials-12-02924-g001.jpg

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