Department of Pharmacognosy, Faculty of Pharmacy, University of Pécs, 7624 Pécs, Hungary.
Department of Microbiology, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary.
Molecules. 2022 Aug 27;27(17):5518. doi: 10.3390/molecules27175518.
The biofilm formation of bacteria in different parts of the human body can influence the success of antibiotic therapy. Essential oils (EOs) and their components are becoming increasingly popular in point of view of medicinal applications, because of their antibacterial efficacy. The immortelle EO has been used traditionally as an expectorant; however, there are no studies summarizing its antibacterial effect against respiratory tract bacteria. Our aim was to investigate the antibacterial and biofilm inhibitory activity of immortelle () EO against respiratory tract pathogens such as , , and . In order to prove the antibacterial effect of the immortelle EO, broth microdilution and biofilm inhibition tests, and membrane damage assay were investigated. Scanning electron microscopy was used to identify the structural modifications in bacterial cells. Our results showed that immortelle EO has antibacterial and anti-biofilm effects against respiratory tract bacteria used in this study. was the most sensitive to each treatment, however, was the most resistant bacteria. In conclusion, the studied EO may have a role in the treatment of respiratory tract infections due to their antibacterial and anti-biofilm activity.
人体不同部位细菌的生物膜形成会影响抗生素治疗的效果。由于具有抗菌功效，精油（EOs）及其成分在药用方面越来越受到关注。作为一种祛痰剂，人们一直以来都在使用法国薰衣草精油，但目前尚无研究对其针对呼吸道细菌的抗菌作用进行总结。我们的目的是研究法国薰衣草（）精油对呼吸道病原体如、、和的抗菌和抑制生物膜活性。为了证明法国薰衣草精油的抗菌效果，我们进行了肉汤微量稀释和生物膜抑制试验以及膜损伤测定。扫描电子显微镜用于鉴定细菌细胞的结构修饰。我们的结果表明，法国薰衣草精油对本研究中使用的呼吸道细菌具有抗菌和抗生物膜作用。每种处理中最敏感的细菌是，而最耐药的细菌是。总之，由于其抗菌和抗生物膜活性，研究中使用的精油可能在治疗呼吸道感染方面发挥作用。
