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（Forssk.）Edgew在预防环磷酰胺诱导的骨髓抑制及调节固有免疫和适应性免疫反应中的药理作用

Pharmacological Role of (Forssk.) Edgew in Preventing Cyclophosphamide-induced Myelosuppression and Modulating Innate and Adaptive Immune Response.

作者信息

Farhan Rasheed Hafiz Muhammad, Jabeen Qaiser

机构信息

Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.

Primary and Secondary Healthcare Department, Government of Punjab, Bahawalpur, Pakistan.

出版信息

Dose Response. 2022 Aug 31;20(3):15593258221123672. doi: 10.1177/15593258221123672. eCollection 2022 Jul-Sep.

DOI:10.1177/15593258221123672
PMID:36081616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9445482/
Abstract

BACKGROUND

(Forssk.) Edgew is reported to be practiced in the traditional system of medicine for the management of various immunological pathologies.

PURPOSE

The current study was designed to evaluate the modulatory effects of on different immune responses.

RESEARCH DESIGN

was extracted in 70% methanol and the crude extract (Cd.Cr) was analyzed by FTIR and GCMS. In vivo models were employed to assess the actions of Cd.Cr on cyclophosphamide-induced myelosuppression, innate and adaptive immune responses.

RESULTS

GCMS and FTIR analysis indicated the presence of flavonoids, phenols, terpenoids and lipids. Cd.Cr evoked a significant and dose-dependent increase in percent neutrophil adhesion (15.97 ± .81, 27.47 ± .79 and 38.35 ± 1.08) and the phagocytic index (3.1 ± .04, 3.96 ± .06 and 5.28 ± .13) at the doses of 30, 100 and 300 mg/kg. Cd.Cr also potentiated haemagglutinating antibody titre, immunoglobulins and cytokines (interferon-γ and interleukin-2) production for 4 weeks, after exposure to sheep erythrocytes, and delayed type hypersensitivity reaction significantly ( < .05). The restoration of hematological profile and antioxidant enzyme activities, by Cd.Cr, indicated the prevention of cyclophosphamide-induced myelosuppression and oxidative stress.

CONCLUSIONS

The findings of this study suggest that holds immunomodulatory activity by thus possesses therapeutic potential for the management of immunological diseases.

摘要

背景

据报道，（Forssk.）Edgew在传统医学体系中用于治疗各种免疫性疾病。

目的

本研究旨在评估其对不同免疫反应的调节作用。

研究设计

用70%甲醇提取，并通过傅里叶变换红外光谱（FTIR）和气相色谱 - 质谱联用（GCMS）分析粗提物（Cd.Cr）。采用体内模型评估Cd.Cr对环磷酰胺诱导的骨髓抑制、固有免疫和适应性免疫反应的作用。

结果

GCMS和FTIR分析表明存在黄酮类、酚类、萜类和脂质。在30、100和300 mg/kg剂量下，Cd.Cr引起中性粒细胞黏附百分比（15.97±.81、27.47±.79和38.35±1.08）和吞噬指数（3.1±.04、3.96±.06和5.28±.13）显著且呈剂量依赖性增加。在接触绵羊红细胞后4周，Cd.Cr还增强了血凝抗体滴度、免疫球蛋白和细胞因子（干扰素 -γ和白细胞介素 -2）的产生，并显著延迟了迟发型超敏反应（P <.05）。Cd.Cr使血液学指标和抗氧化酶活性恢复，表明其可预防环磷酰胺诱导的骨髓抑制和氧化应激。

结论

本研究结果表明具有免疫调节活性，因此对免疫性疾病的治疗具有潜在价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ab/9445482/52ba18ccbf22/10.1177_15593258221123672-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ab/9445482/1494851e3477/10.1177_15593258221123672-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ab/9445482/8c4f66811959/10.1177_15593258221123672-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ab/9445482/d1c5e1f88bd0/10.1177_15593258221123672-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ab/9445482/67527da2b58d/10.1177_15593258221123672-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ab/9445482/3a07ee10e9c7/10.1177_15593258221123672-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ab/9445482/52ba18ccbf22/10.1177_15593258221123672-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ab/9445482/1494851e3477/10.1177_15593258221123672-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ab/9445482/8c4f66811959/10.1177_15593258221123672-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ab/9445482/d1c5e1f88bd0/10.1177_15593258221123672-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ab/9445482/67527da2b58d/10.1177_15593258221123672-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ab/9445482/3a07ee10e9c7/10.1177_15593258221123672-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ab/9445482/52ba18ccbf22/10.1177_15593258221123672-fig6.jpg

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