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2019冠状病毒病优先地理区域疫苗接种的优化分配策略

Optimal allocation strategies for prioritized geographical vaccination for Covid-19.

作者信息

Ghazal Ikram, Rachadi Abdeljalil, Ez-Zahraouy Hamid

机构信息

Laboratoire de Matière Condensée et des Sciences Interdisciplinaires (LaMCScI), Unité de recherche labellisée CNRST, Faculté des Sciences, Université Mohammed V de Rabat, B.P. 1014, Morocco.

出版信息

Physica A. 2022 Dec 1;607:128166. doi: 10.1016/j.physa.2022.128166. Epub 2022 Sep 6.

DOI:10.1016/j.physa.2022.128166
PMID:36090308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9446606/
Abstract

While SARS-CoV-2 vaccine distribution campaigns are underway across the world communities, these efforts face the challenge of effective distribution of limited supplies. We wonder whether suitable spatial allocation strategies might significantly improve a campaignfls efficacy in averting damaging outcomes. In the context of a limited and intermittent COVID-19 supply, we investigate spatial prioritization strategies based on six metrics using the SLIR compartmental epidemic model. We found that the strategy based on the prevalence of susceptible individuals is optimal especially in early interventions and for intermediate values of vaccination rate. It minimizes the cumulative incidence and consequently averts most infections. Our results suggest also that a better performance is obtained if the single batch allocation is supplemented with one or more updating of the priority list. Moreover, the splitting of supply in two or more batches may significantly improve the optimality of the operation.

摘要

虽然全球各地社区都在开展严重急性呼吸综合征冠状病毒2(SARS-CoV-2)疫苗接种运动,但这些努力面临着有效分配有限供应品的挑战。我们想知道合适的空间分配策略是否能显著提高运动在避免破坏性后果方面的效果。在新冠病毒19(COVID-19)供应有限且断断续续的情况下,我们使用易感-潜伏-感染-康复(SLIR)分区流行模型,基于六个指标研究空间优先级策略。我们发现,基于易感个体患病率的策略是最优的,尤其是在早期干预和中等疫苗接种率的情况下。它能将累计发病率降至最低,从而避免大多数感染。我们的结果还表明,如果在单次批次分配的基础上对优先级列表进行一次或多次更新,会取得更好的效果。此外,将供应品分成两批或更多批可能会显著提高操作的最优性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b2/9446606/6e33cd01c5b3/gr7_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b2/9446606/0911ae0f0e12/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b2/9446606/1870b78e0782/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b2/9446606/db1468fe3356/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b2/9446606/1433db2dfe27/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b2/9446606/5af343aca45a/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b2/9446606/8f150a85e947/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b2/9446606/6e33cd01c5b3/gr7_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b2/9446606/0911ae0f0e12/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b2/9446606/1870b78e0782/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b2/9446606/db1468fe3356/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b2/9446606/1433db2dfe27/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b2/9446606/5af343aca45a/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b2/9446606/8f150a85e947/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b2/9446606/6e33cd01c5b3/gr7_lrg.jpg

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本文引用的文献

1
The optimal allocation of Covid-19 vaccines.新冠疫苗的优化分配
Econ Lett. 2023 Mar;224:111008. doi: 10.1016/j.econlet.2023.111008. Epub 2023 Jan 31.
2
Optimal control of the spatial allocation of COVID-19 vaccines: Italy as a case study.优化 COVID-19 疫苗的空间分配的最优控制:以意大利为例。
PLoS Comput Biol. 2022 Jul 8;18(7):e1010237. doi: 10.1371/journal.pcbi.1010237. eCollection 2022 Jul.
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PLoS Comput Biol. 2021 May 6;17(5):e1008849. doi: 10.1371/journal.pcbi.1008849. eCollection 2021 May.
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Dynamic prioritization of COVID-19 vaccines when social distancing is limited for essential workers.在社交距离对基本工人有限时,对 COVID-19 疫苗进行动态优先级排序。
Proc Natl Acad Sci U S A. 2021 Apr 20;118(16). doi: 10.1073/pnas.2025786118.
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Optimal Allocation of the Limited COVID-19 Vaccine Supply in South Korea.韩国有限新冠疫苗供应的优化分配
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Science. 2021 Feb 26;371(6532):916-921. doi: 10.1126/science.abe6959. Epub 2021 Jan 21.
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Comparing COVID-19 vaccine allocation strategies in India: A mathematical modelling study.比较印度的 COVID-19 疫苗分配策略:一项数学建模研究。
Int J Infect Dis. 2021 Feb;103:431-438. doi: 10.1016/j.ijid.2020.12.075. Epub 2020 Dec 31.
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