额颞叶痴呆中的过度进食：疾病早期的认知和精神症状特征。
Hyperorality in Frontotemporal Dementia: Cognitive and Psychiatric Symptom Profiles in Early-Stage Disease.
机构信息
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
University of Maryland Medical Center, Baltimore, MD, USA.
出版信息
J Alzheimers Dis. 2022;89(4):1203-1209. doi: 10.3233/JAD-220443.
Abstract
Hyperorality is a distinctive feature of the behavioral variant of frontotemporal dementia (bvFTD), but little is known about its significance in early-stage disease. This study examined the cognitive and psychiatric symptom profiles associated with hyperorality, using data from subjects with early-stage bvFTD enrolled in Alzheimer's Disease Research Centers. We found that hyperorality was not associated with cognitive performance, but was associated with psychosis, elation, and disinhibition. Hyperorality may share neurobiology with a subset of early psychiatric symptoms, a finding which could help identify targets for future treatment.
摘要
过度饮食是额颞叶痴呆（bvFTD）行为变异型的一个显著特征，但人们对其在疾病早期阶段的意义知之甚少。本研究使用阿尔茨海默病研究中心早期 bvFTD 患者的数据，考察了与过度饮食相关的认知和精神症状特征。我们发现，过度饮食与认知表现无关，但与精神病、欣快和抑制障碍有关。过度饮食可能与早期精神症状的亚组具有相同的神经生物学基础，这一发现有助于确定未来治疗的靶点。
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