Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.
Mol Syst Biol. 2022 Sep;18(9):e11276. doi: 10.15252/msb.202211276.
Assessing age-related tissue dysfunction represents an emerging field and involves analyses that are far from trivial, often requiring the integration of several large-scale ("omic") techniques. In their recent work, Tessarz and colleagues (Bozukova et al, 2022) characterize changes in the transcriptional machinery during aging in mice and report some surprising findings.
评估与年龄相关的组织功能障碍是一个新兴领域，涉及的分析远非微不足道，通常需要整合几种大规模（“组学”）技术。在他们最近的工作中，Tessarz 及其同事（Bozukova 等人，2022 年）描述了小鼠衰老过程中转录机制的变化，并报告了一些令人惊讶的发现。
