Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, Iran.
Department of Medical Biotechnology, Faculty of Paramedicine, Qazvin University of Medical Sciences, Qazvin 15315-34199, Iran.
Molecules. 2019 Nov 7;24(22):4029. doi: 10.3390/molecules24224029.
Curcumin has been placed at the forefront of the researcher's attention due to its pleiotropic pharmacological effects and health benefits. A considerable volume of articles has pointed out curcumin's effects on the fate of stem cell differentiation. In this review, a descriptive mechanism of how curcumin affects the outcome of the differentiation of mesenchymal stem cells (MSCs) into the mesodermal lineage-i.e., adipocyte, osteocyte, and chondrocyte differentiation-is compiled from the literature. The sections include the mechanism of inhibition or induction of MSCs differentiation to each lineage, their governing molecular mechanisms, and their signal transduction pathways. The effect of different curcumin doses and its structural modifications on the MSCs differentiation is also discussed.
姜黄素因其多效的药理作用和健康益处而成为研究人员关注的焦点。大量的文章指出了姜黄素对干细胞分化命运的影响。在这篇综述中，我们从文献中整理出了姜黄素影响间充质干细胞（MSCs）向中胚层谱系（即脂肪细胞、成骨细胞和软骨细胞分化）分化结果的描述性机制。这些部分包括抑制或诱导 MSCs 向每个谱系分化的机制、它们的调控分子机制及其信号转导途径。还讨论了不同剂量的姜黄素及其结构修饰对 MSCs 分化的影响。
