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一项评估抗生素在牙周翻瓣手术中作用的比较临床研究。

A Comparative Clinical Study to Assess the Role of Antibiotics in Periodontal Flap Surgery.

作者信息

Singhi Arpit, Sharma Anant Raghav, Nath Jishnu, Sharma Sangeeta, Marri Ranjitha, Ekka Rashmi Kiran

机构信息

Department of Periodontology, Vyas Dental College, Jodhpur, Rajasthan, India.

Department of Periodontology, Pacific Dental College and Hospital, Udaipur, Rajasthan, India.

出版信息

J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S841-S844. doi: 10.4103/jpbs.jpbs_16_22. Epub 2022 Jul 13.

Abstract

INTRODUCTION

Periodontitis is a multifaceted disease that results from the intricate interplay of infectious pathogens and host factors. Periodontal surgical techniques may be required in moderate to severe cases of chronic periodontitis. As a result of the potential for postoperative infection to have a substantial impact on the surgical outcome, an attempt will be made in the study to assess the role of antibiotics in periodontal flap procedures in minimizing postoperative infections.

METHODOLOGY

From the Department of Periodontics and Oral Implantology, 30 patients (male and female) with moderate to severe chronic periodontitis were chosen. Amoxicillin 500 mg three times a day for 5 days following surgery was given in the therapeutic group (15 patients). Antibiotics were not provided to the control group (15 patients) after surgery. Both groups were administered analgesics and antiseptic mouthwash. On the seventh day after suture removal, patients were assessed for pain (measured on a visual analogue scale [VAS]), modified gingival index, wound healing index, swelling, fever, ulceration, and delayed wound healing.

RESULTS

The VAS reported in the control group was 2.67, while the VAS recorded in the therapeutic group was 2.20. The mean modified gingival index score in the control group was 0.94, while it was 0.67 in the therapeutic group. The mean Wound Healing Index score in the control group was 3.80, whereas it was 3.97 in the therapeutic group. When antibiotics were administered to patients, they reported less pain and faster wound healing. Following flap surgery with or without antibiotics, however, there were no statistically significant variations in all clinical measures.

CONCLUSION

The findings of our study imply that antibiotics for the sole goal of avoiding postsurgical infections may not be beneficial.

摘要

引言

牙周炎是一种多方面的疾病,由感染病原体与宿主因素的复杂相互作用引起。中度至重度慢性牙周炎病例可能需要牙周手术技术。由于术后感染有可能对手术结果产生重大影响,本研究将尝试评估抗生素在牙周瓣手术中对减少术后感染的作用。

方法

从牙周病与口腔种植科选取30例(男女皆有)中度至重度慢性牙周炎患者。治疗组(15例患者)在术后给予阿莫西林500毫克,每日三次,共5天。对照组(15例患者)术后未使用抗生素。两组均给予镇痛药和抗菌漱口水。在拆线后第七天,对患者进行疼痛评估(采用视觉模拟评分法[VAS]测量)、改良牙龈指数、伤口愈合指数、肿胀、发热、溃疡和伤口愈合延迟情况评估。

结果

对照组报告的VAS评分为2.67,而治疗组记录的VAS评分为2.20。对照组的平均改良牙龈指数评分为0.94,而治疗组为0.67。对照组的平均伤口愈合指数评分为3.80,而治疗组为3.97。当给患者使用抗生素时,他们报告的疼痛较轻,伤口愈合较快。然而,在进行瓣手术时无论是否使用抗生素,所有临床指标均无统计学上的显著差异。

结论

我们的研究结果表明,仅以避免术后感染为目的使用抗生素可能并无益处。

相似文献

本文引用的文献

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Periodontal microbial ecology.牙周微生物生态学
Periodontol 2000. 2005;38:135-87. doi: 10.1111/j.1600-0757.2005.00107.x.

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