Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.
The Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center, Farmington, Connecticut 06030, United States.
ACS Appl Mater Interfaces. 2022 Sep 28;14(38):42804-42811. doi: 10.1021/acsami.2c05556. Epub 2022 Sep 16.
The legalization of hemp cultivation in the United States has caused the price of hemp-derived cannabinoids to decrease 10-fold within 2 years. Cannabidiol (CBD), one of many naturally occurring diols found in hemp, can be purified in high yield for low cost, making it an interesting candidate for polymer feedstock. In this study, two polyesters were synthesized from the condensation of either CBD or cannabigerol (CBG) with adipoyl chloride. Poly(CBD-Adipate) was cast into free-standing films and subjected to thermal, mechanical, and biological characterization. Poly(CBD-Adipate) films exhibited a lack of cytotoxicity toward adipose-derived stem cells while displaying an inherent antioxidant activity compared to poly(lactide) films. Additionally, this material was found to be semi-crystalline and able to be melt-processed into a plastic hemp leaf using a silicone baking mold.
美国对大麻种植的合法化导致大麻衍生大麻素的价格在 2 年内降低了 10 倍。大麻二醇（CBD）是大麻中发现的许多天然二醇之一，可以通过高收率低成本进行纯化，因此它是一种有趣的聚合物原料候选物。在这项研究中，两种聚酯是通过 CBD 或大麻二酚（CBG）与己二酰氯缩合而成的。聚（CBD-己二酸酯）被浇铸成独立的薄膜，并进行热、机械和生物特性分析。与聚（丙交酯）薄膜相比，聚（CBD-己二酸酯）薄膜对脂肪来源的干细胞没有细胞毒性，同时表现出固有的抗氧化活性。此外，这种材料被发现是半结晶的，并且能够使用硅橡胶烘焙模具将其熔融加工成塑料大麻叶。
