Nyrén O, Adami H O, Gustavsson S, Lindgren P G, Lööf L, Nyberg A
J Clin Gastroenterol. 1987 Jun;9(3):303-9.
Nonucler dyspepsia lacks a clear definition, and probably conceals several entities under this heading. It seems appropriate to deal separately with symptoms likely to be elicited from the upper digestive tract. Therefore, we propose "epigastric distress syndrome" (EDS) as a designation for chronic or recurrent epigastric pain without any anatomical antecedents and without concomitant symptoms consistent with established criteria of the irritable bowel syndrome. In this study 185 dyspeptic patients with a tentative diagnosis of EDS, based on symptoms and negative upper endoscopy, underwent laboratory screening, peroral cholecystograms, ultrasound scanning of the liver, biliary tract, and pancreas, biopsies from the distal part of the duodenum, and acid secretory tests. There were very few pathological findings. Five patients had gallstones. No single case of chronic pancreatitis or celiac disease was disclosed. Thus, EDS seems to be a "safe" diagnosis, and it is not unreasonable to assume that it could represent a disease entity. Although many patients had symptoms closely similar to those in duodenal ulcer, the mean basal and maximal acid output in this patient category did not differ from that observed among healthy subjects.
非溃疡性消化不良没有明确的定义，在这个名称下可能隐藏着多种情况。分别处理可能由上消化道引发的症状似乎是合适的。因此，我们提出“上腹部不适综合征”（EDS）来指代无任何解剖学病因且无符合肠易激综合征既定标准的伴随症状的慢性或复发性上腹部疼痛。在本研究中，185例基于症状和上消化道内镜检查阴性而初步诊断为EDS的消化不良患者接受了实验室筛查、口服胆囊造影、肝脏、胆道和胰腺的超声扫描、十二指肠远端活检以及胃酸分泌试验。病理发现极少。5例患者有胆结石。未发现1例慢性胰腺炎或乳糜泻病例。因此，EDS似乎是一种“安全”的诊断，且可以合理地假设它可能代表一种疾病实体。尽管许多患者的症状与十二指肠溃疡患者的症状极为相似，但该类患者的基础胃酸分泌量和最大胃酸分泌量均值与健康受试者中观察到的并无差异。
