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内蒙古绒山羊中长链非编码RNA的表达谱及其在毛囊发育中的潜在作用

Expression profile of long non-coding RNA in inner Mongolian cashmere goat with putative roles in hair follicles development.

作者信息

Ma Rong, Shang Fangzheng, Rong Youjun, Pan Jianfeng, Wang Min, Niu Shuran, Qi Yunpeng, Li Yanbo, Lv Qi, Wang Zhiying, Wang Ruijun, Su Rui, Liu Zhihong, Zhao Yanhong, Wang Zhixin, Li Jinquan, Zhang Yanjun

机构信息

College of Animal Science, Inner Mongolia Agricultural University, Hohhot, China.

Key Laboratory of Mutton Sheep Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Hohhot, China.

出版信息

Front Vet Sci. 2022 Sep 2;9:995604. doi: 10.3389/fvets.2022.995604. eCollection 2022.

DOI:10.3389/fvets.2022.995604
PMID:36118352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9478897/
Abstract

The hair follicle is a complex skin accessory organ, which determines hair growth. Long non-coding RNAs (lncRNAs) have been proven to play an important role in hair follicle development, but their specific mechanism is still unclear. In this study, high-throughput sequencing was used to obtain the expression profiles of lncRNA in the hair follicles of Inner Mongolian cashmere goats at different embryonic stages (45, 55, 65, and 75 days), and a total of 6,630 lncRNA were identified. According to the rules of hair follicle development, we combined miRNA and mRNA databases (published) and predicted lncRNA-miRNA, miRNA-mRNA, and lncRNA-mRNA interaction pairs in the 45 vs. 75 comparison group. We obtained 516 lncRNA-mRNA, 1,011 lncRNA-miRNA, and 7,411 miRNA-mRNA relationship pairs. Finally, target genes were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), and it was found that they were mainly enriched in the Wnt signaling pathway and PI3K-Akt signaling pathway related to hair follicle development, indicating that lncRNA may interact with miRNA/mRNA to directly or indirectly regulate the expression of genes related to hair follicle development. Dual-luciferase reporter gene analysis showed that could bind to , while had no binding site for . In conclusion, this study aims to further analyze the molecular regulation mechanism of hair follicle development and to lay a theoretical foundation for revealing the regulation mechanism of cashmere hair follicle growth.

摘要

毛囊是一种复杂的皮肤附属器官，它决定毛发的生长。长链非编码RNA（lncRNAs）已被证明在毛囊发育中起重要作用，但其具体机制仍不清楚。在本研究中，利用高通量测序获得了内蒙古绒山羊不同胚胎阶段（45、55、65和75天）毛囊中lncRNA的表达谱，共鉴定出6630个lncRNA。根据毛囊发育规律，我们结合miRNA和mRNA数据库（已发表），并在45天与75天的比较组中预测了lncRNA-miRNA、miRNA-mRNA和lncRNA-mRNA相互作用对。我们获得了516个lncRNA-mRNA、1011个lncRNA-miRNA和7411个miRNA-mRNA关系对。最后，通过基因本体论（GO）和京都基因与基因组百科全书（KEGG）对靶基因进行分析，发现它们主要富集在与毛囊发育相关的Wnt信号通路和PI3K-Akt信号通路中，表明lncRNA可能与miRNA/mRNA相互作用，直接或间接调节与毛囊发育相关基因的表达。双荧光素酶报告基因分析表明， 可与 结合，而 对 没有结合位点。总之，本研究旨在进一步分析毛囊发育的分子调控机制，为揭示绒山羊毛囊生长调控机制奠定理论基础。

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