Yang Jian-Bo, Sun Hua, Ma Jie, Song Yun-Fei, Liu Yue, Wang Qi, Ma Shuang-Cheng, Cheng Xian-Long, Wei Feng
Research and Inspection Center of Traditional Chinese Medicine and Ethnomedicine, National Institutes for Food and Drug Control, State Food and Drug Administration, Beijing 100050, China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Chin Herb Med. 2020 Jul 2;12(3):342-346. doi: 10.1016/j.chmed.2020.02.001. eCollection 2020 Jul.
To isolate the phenolic compounds obtained from the dried roots of and investigate their pharmacological activities.
The chemical constituents were isolated and purified by combining them with a macroporous resin (DM-8), MCI gel, and Sephadex LH-20 and by performing ODS column chromatography. Their structures were elucidated by 1D and 2D NMR analyses, as well as mass spectrometry. The isolated compounds were evaluated to determine their hepatoprotective and α-glucosidase inhibitory activities .
Two phenolic compounds, namely, polygonimitin E () and polygonimitin F (), were isolated from the dried roots of . Compound (10 µmol/L) only showed moderate hepatoprotective activity against -acetyl-p-aminophenol (APAP)-induced HepG2 cell damage. Unfortunately, these two compounds exhibited no α-glucosidase inhibitory activity.
Compounds and were new compounds. Compound could be one of the potential hepatoprotective constituents of .
从[植物名称]干燥根中分离酚类化合物并研究其药理活性。
通过与大孔树脂（DM - 8）、MCI凝胶和葡聚糖凝胶LH - 20结合并进行ODS柱色谱法分离和纯化化学成分。通过一维和二维核磁共振分析以及质谱法阐明其结构。对分离出的化合物进行评估以确定其保肝和α - 葡萄糖苷酶抑制活性。
从[植物名称]干燥根中分离出两种酚类化合物，即虎杖苷E（[化合物具体结构]）和虎杖苷F（[化合物具体结构]）。化合物[具体编号]（10 μmol/L）仅对乙酰对氨基酚（APAP）诱导的HepG2细胞损伤表现出中等程度的保肝活性。遗憾的是，这两种化合物均未表现出α - 葡萄糖苷酶抑制活性。
化合物[具体编号]和[具体编号]为新化合物。化合物[具体编号]可能是[植物名称]潜在的保肝成分之一。
