Alsolaimi Yaseer A, Almudaymigh Mohammed S, Al Essa Mohammed, Gramish Jawaher, Bustami Rami, Al Yami Majed S, Vasudevan Senthilvel
Department of Pharmacy Practice, College of Pharmacy, King Saud Bin Abdul-Aziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia.
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
J Family Med Prim Care. 2022 Jun;11(6):2399-2404. doi: 10.4103/jfmpc.jfmpc_601_21. Epub 2022 Jun 30.
Diabetic retinopathy is called as vision threatening disease. It affects retina very severely. DR is a common public health problem in Worldwide. Our main objective was to identify significant risk factors for diabetic retinopathy among diabetes mellitus patients.
The present retrospective Case-Control study was conducted with 404 DM patients' records were collected from King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Data were presented as descriptive statistics, multivariate logistic regression, association between variables was using odds ratio and 95% confidence interval.
Among 404 diabetes patients, 192 (47.5%) were Cases and 212 (52.5%) Controls. In multivariate regression analysis showed that male gender also had a higher likelihood in the development of DR, OR: 1. 68 [95% CI: (1.04 - 2.71); p<0.05]. Patients with poor glycaemic control, OR: 4. 86 [95% CI: (2.21-10.66); p<0.001]. Similarly, HbA1C, Low LDL was prominent risk factor in the progression of DR except age, hypocholesterolaemia, nephropathy wasn't significant.
From our study findings, male gender, tobacco habit, poor glycaemic control, and Low HDL were appeared independently associated with the development of vision-threatening disease. By regular check-up, reducing risk factors or retain their stages in the same stage or to prolong the DR incidents among DM patients.
糖尿病视网膜病变被称为威胁视力的疾病。它对视网膜的影响非常严重。糖尿病视网膜病变是全球常见的公共卫生问题。我们的主要目标是确定糖尿病患者中糖尿病视网膜病变的重要危险因素。
本回顾性病例对照研究收集了沙特阿拉伯利雅得阿卜杜勒阿齐兹国王医疗城404例糖尿病患者的记录。
数据以描述性统计、多因素逻辑回归呈现，变量间的关联采用比值比和95%置信区间。
在404例糖尿病患者中，192例（47.5%）为病例组，212例（52.5%）为对照组。多因素回归分析显示，男性患糖尿病视网膜病变的可能性也更高，比值比：1.68 [95%置信区间：(1.04 - 2.71)；p<0.05]。血糖控制不佳的患者，比值比：4.86 [95%置信区间：(2.21 - 10.66)；p<0.001]。同样，糖化血红蛋白、低密度脂蛋白低是糖尿病视网膜病变进展的突出危险因素，年龄、低胆固醇血症、肾病除外，差异无统计学意义。
根据我们的研究结果，男性、吸烟习惯、血糖控制不佳和高密度脂蛋白低与威胁视力疾病的发生独立相关。通过定期检查，降低危险因素或使糖尿病患者的病情保持在同一阶段或延长糖尿病视网膜病变的发病时间。
