Court J, Ferrier N, Griffiths H, Lauffart B, Perry R, Candy J, Fairbairn A, Blessed G
J Neurol Sci. 1987 Aug;80(1):111-5. doi: 10.1016/0022-510x(87)90225-5.
A rise in serum creatine kinase-BB (CK-BB) levels has been reported previously in cases of dementia. In the present study the levels of serum CK-BB have been measured in patients clinically assessed to have senile dementia of the Alzheimer's type (SDAT) and in cognitively intact individuals, matched for age, by a specific two-site monoclonal immunoradiometric assay. No significant difference was found between the 2 groups. Total creatine kinase activity in temporal cortex (Brodmann area 21 and 22) was also found to be similar in brains from SDAT or control cases, obtained at autopsy. These results suggest no major change in the permeability of the blood-brain barrier to this enzyme in SDAT patients.
先前已有报道称，痴呆患者血清肌酸激酶 - BB（CK - BB）水平会升高。在本研究中，通过一种特定的双位点单克隆免疫放射分析方法，对临床评估为阿尔茨海默型老年痴呆（SDAT）的患者以及年龄匹配的认知功能正常个体的血清CK - BB水平进行了测量。两组之间未发现显著差异。在尸检获得的SDAT患者或对照病例的大脑中，还发现颞叶皮质（布罗德曼21区和22区）的总肌酸激酶活性相似。这些结果表明，在SDAT患者中，血脑屏障对这种酶的通透性没有重大变化。
