Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Mol Oncol. 2022 Sep;16(18):3213-3219. doi: 10.1002/1878-0261.13302.
Many cancers show an increase in incidence with age, and age is the biggest single risk factor for many cancers. However, the molecular basis of this relationship is poorly understood. Through a collection of review articles, our thematic issue discusses the link between aging and cancer in aspects including somatic mutations, proteostasis, mitochondria, metabolism, senescence, epigenetic regulation, immune regulation, DNA damage, and telomere function.
许多癌症的发病率随年龄增长而增加，年龄是许多癌症的最大单一风险因素。然而，这种关系的分子基础还了解甚少。通过一系列评论文章，本期特刊从体细胞突变、蛋白质稳态、线粒体、代谢、衰老、表观遗传调控、免疫调控、DNA 损伤和端粒功能等方面讨论了衰老与癌症之间的联系。
