Research Institute of Pharmaceutical Sciences, College of Pharmacy, Chonnam National University, Gwangju 61186, Korea.
College of Pharmacy, Gachon University, Incheon 21936, Korea.
Mar Drugs. 2022 Sep 5;20(9):565. doi: 10.3390/md20090565.
Three new secondary metabolites, actinoflavosides B-D (-), were discovered in the culture broth of two actinomycete strains (JML48 and JMS33) that were isolated from tidal mudflat sediment in Muan, Republic of Korea. The planar structures of the actinoflavosides were elucidated by MS, UV, and NMR analyses. The stereochemistry of an aminosugar, 2,3,6-trideoxy-3-amino-ribopyranoside in the actinoflavosides was determined by -based configuration analysis using values obtained from DQF-COSY experiments and modified Mosher's method. Actinoflavosides B-D (-) displayed antibacterial activity against , and actinoflavoside D () significantly increased IL-2 production in mouse splenocytes.
从韩国务安潮汐滩涂沉积物中分离到的 2 株放线菌（JML48 和 JMS33）的发酵液中发现了 3 种新的次生代谢产物——actinoflavosides B-D(-)。通过 MS、UV 和 NMR 分析阐明了 actinoflavosides 的平面结构。通过 DQF-COSY 实验和改良的 Mosher 法获得的 值，基于构型分析确定了 actinoflavosides 中氨基糖 2,3,6-三脱氧-3-氨基-核糖吡喃糖苷的立体化学。Actinoflavosides B-D(-)对 表现出抗菌活性，并且 actinoflavoside D()显著增加了小鼠脾细胞中 IL-2 的产生。
