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从sp. CMS18中分离生物活性化合物及其特性与抗真菌性能研究

Isolation and Characterization of Bioactive Compounds from sp. CMS18 and Their Antifungal Properties.

作者信息

Um Soohyun, Jeong Hyeongju, Park Ji-Eun, Seo Jeongwon, Jung Sang Heon, Bae Munhyung, Lee Kyung-Tae, Moon Kyuho

机构信息

College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.

Research Institute of Pharmaceutical Sciences, College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea.

出版信息

Mar Drugs. 2024 Nov 30;22(12):539. doi: 10.3390/md22120539.

DOI:10.3390/md22120539
PMID:39728114
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11677142/
Abstract

In this study, metagenomic analysis was employed to investigate the bacterial communities in the Muan tidal mudflat of the Republic of Korea. We used metagenomic analysis to identify the microbial community in tidal soil dominated by Proteobacteria. From this environment, the bacterial strain, sp. CMS18, was isolated and yielded two previously unknown compounds, penipaline D () and -acetyl-dimethylallyltryptophan (). The chemical structures of the isolated compounds along with 6-dimethylallyl-indole (), 6-dimethylallyltryptophan (), penipaline D (), and -acetyl-dimethylallyltryptophan () were structurally investigated using HR-ESI-MS and NMR spectroscopy. The isolated compound 6-dimethylallyl-indole () demonstrated broad-spectrum antifungal activity, with IC value of 0.04 mM against and 0.35 mM against both and . Additionally, it exhibited additive interaction with caspofungin against .

摘要

在本研究中，采用宏基因组分析来调查大韩民国务安潮汐泥滩中的细菌群落。我们使用宏基因组分析来鉴定以变形菌门为主导的潮汐土壤中的微生物群落。从该环境中分离出细菌菌株sp. CMS18，并产生了两种以前未知的化合物，penipaline D（）和 - 乙酰 - 二甲基烯丙基色氨酸（）。使用高分辨率电喷雾电离质谱（HR-ESI-MS）和核磁共振光谱（NMR）对分离出的化合物以及6 - 二甲基烯丙基吲哚（）、6 - 二甲基烯丙基色氨酸（）、penipaline D（）和 - 乙酰 - 二甲基烯丙基色氨酸（）的化学结构进行了研究。分离出的化合物6 - 二甲基烯丙基吲哚（）表现出广谱抗真菌活性，对的IC值为0.04 mM，对和的IC值均为0.35 mM。此外，它与卡泊芬净对表现出相加作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f7/11677142/4de0e820a64e/marinedrugs-22-00539-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f7/11677142/756338677afe/marinedrugs-22-00539-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f7/11677142/febc7b0f6a45/marinedrugs-22-00539-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f7/11677142/d927ed78ef7d/marinedrugs-22-00539-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f7/11677142/9a2410806d45/marinedrugs-22-00539-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f7/11677142/4de0e820a64e/marinedrugs-22-00539-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f7/11677142/756338677afe/marinedrugs-22-00539-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f7/11677142/febc7b0f6a45/marinedrugs-22-00539-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f7/11677142/d927ed78ef7d/marinedrugs-22-00539-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f7/11677142/9a2410806d45/marinedrugs-22-00539-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f7/11677142/4de0e820a64e/marinedrugs-22-00539-g005.jpg

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Cystargamides C and D, New Cyclic Lipopeptides From a Tidal Mudflat-Derived sp. JMS132.胱氨酸酰胺C和D，来自潮间带泥滩来源的新环脂肽，sp. JMS132。
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Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection.
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16S rRNA gene amplicon-based metagenomic analysis of bacterial communities in the rhizospheres of selected mangrove species from Mida Creek and Gazi Bay, Kenya.基于 16S rRNA 基因扩增子的宏基因组分析肯尼亚米达湾和加济湾选定红树林物种根际细菌群落。
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