School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Beutenbergstraße 11a, 07745 Jena, Germany.
J Nat Prod. 2020 Oct 23;83(10):3102-3110. doi: 10.1021/acs.jnatprod.0c00676. Epub 2020 Sep 18.
Based on high-resolution tandem mass spectrometry (HR-MS) and global natural products social molecular networking (GNPS), we found that plant-derived daidzein and genistein derivatives are polyhalogenated by termite-associated species RB99. MS-guided purification from extracts of bacteria grown under optimized conditions led to the isolation of eight polychlorinated isoflavones, including six unreported derivatives, and seven novel polybrominated derivatives, two of which showed antimicrobial activity.
基于高分辨率串联质谱（HR-MS）和全球天然产物社会分子网络（GNPS），我们发现由白蚁相关物种 RB99 多卤化的植物源性大豆苷元和染料木黄酮衍生物。从优化条件下培养的细菌提取物中进行 MS 导向的纯化，导致分离出八种多氯异黄酮，包括六种未报道的衍生物，以及七种新的多溴衍生物，其中两种具有抗菌活性。
