Wilson J R, Nagoshi C T
Alcohol Research Center, Institute for Behavioral Genetics, Boulder, Colorado.
J Stud Alcohol. 1987 Sep;48(5):437-42. doi: 10.15288/jsa.1987.48.437.
Subjects (N = 34) in the Colorado Alcohol Research on Twins and Adoptees (CARTA) were brought back between 30 and 60 days after their initial testing to be retested on all the CARTA procedures. As before, subjects were given a dose of alcohol (.8 g/kg of body weight) calculated to bring their blood alcohol level (BAL) to near 100 mg/dl. Additional doses were given at the end of each of the next 2 hours to maintain their BAL near peak for approximately 3 hours. Repeatability (test-retest correlation) for alcohol clearance rate was near 0, with repeatabilities between .40 and .55 for peak BAL, time-to-peak BAL, average session BAL and relative volume of alcohol distribution. Repeatabilities of prealcohol baseline scores were generally high (median, .71) for the CARTA battery of physiological, motor coordination, perceptual speed and reaction time measures, but were only low to moderate for sensitivity scores (median, .27) and acute tolerance scores (median, .25) calculated on these measures. There was some evidence that repeatabilities for alcohol metabolism, sensitivity and acute tolerance were lower for women than for men.
科罗拉多双胞胎与领养者酒精研究（CARTA）中的受试者（N = 34）在首次测试后的30至60天内被召回，对所有CARTA程序进行重新测试。和之前一样，给受试者服用一定剂量的酒精（0.8克/千克体重），计算得出这会使他们的血液酒精浓度（BAL）接近100毫克/分升。在接下来的2小时结束时，再给予额外剂量以维持他们的BAL在峰值附近约3小时。酒精清除率的重复性（重测相关性）接近0，峰值BAL、达到峰值BAL的时间、平均测试时段BAL以及酒精分布相对体积的重复性在0.40至0.55之间。对于CARTA一系列生理、运动协调、感知速度和反应时间测量，酒精摄入前基线分数的重复性通常较高（中位数为0.71），但基于这些测量计算的敏感性分数（中位数为0.27）和急性耐受性分数（中位数为0.25）的重复性仅为低到中等。有一些证据表明，女性在酒精代谢、敏感性和急性耐受性方面的重复性低于男性。
