Puccini Valentina
Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Sports (Basel). 2022 Aug 31;10(9):131. doi: 10.3390/sports10090131.
It is widely recognized that athletes consume oral antibiotics almost twice as often as observed in the non-sports population in order to reduce as much as possible the period of inactivity due to bacterial diseases. However, increasing evidences have demonstrated the ability of some classes of antibiotics to induce muscle weakness, pain, and a feeling of fatigue upon resuming physical activity conditions that considerably limit the athletic performance of athletes, ascribable to alterations in the biochemical mechanisms underlying normal musculoskeletal activity, such as mitochondrial respiration. For this reason, tailoring a treatment plan for effective antibiotics that limit an athlete's risk is paramount to their safety and ability to maintain adequate athletic performance. The present review illustrates and critically analyzes the evidence on the use of antibiotics in sports, deepening the molecular mechanisms underlying the onset and development of muscle-tendon alterations in athletes as well as delineating the pharmacological strategies aimed at counteracting such adverse events.
人们普遍认识到，运动员口服抗生素的频率几乎是非运动员人群的两倍，以便尽可能缩短因细菌性疾病而导致的不活动期。然而，越来越多的证据表明，某些种类的抗生素能够在恢复体育活动时诱发肌肉无力、疼痛和疲劳感，这在很大程度上限制了运动员的运动表现，这归因于正常肌肉骨骼活动背后的生化机制（如线粒体呼吸）的改变。因此，制定一个有效的抗生素治疗方案以降低运动员的风险，对于他们的安全和维持足够运动表现的能力至关重要。本综述阐述并批判性地分析了有关体育领域使用抗生素的证据，深入探讨了运动员肌腱改变发生和发展的分子机制，并描述了旨在对抗此类不良事件的药理学策略。
