Wu Chao, Huang Xing, Li Mao, Wang Zihe, Zhang Yi, Tian Bole
Department of General Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Department of Pancreatic Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, Sichuan Province, China.
Future Oncol. 2022 Dec;18(40):4525-4538. doi: 10.2217/fon-2022-0429. Epub 2023 Mar 9.
Evidence indicates that circular RNAs (circRNAs) may play an important role in regulating gene expression by binding to miRNAs through miRNA response elements. circRNAs are formed by back-splicing and have a covalently closed structure. The biogenesis of circRNAs also appears to be regulated by certain cell-specific and/or gene-specific mechanisms, and thus some circRNAs are tissue specific and tumor-expression specific. Furthermore, the high stability and tissue specificity of circRNAs may be of value for early diagnosis, survival prediction and precision medicine. This review summarizes current knowledge regarding the classification and functions of circRNAs and the role of circRNAs in regulating the PI3K/AKT and/or MEK/ERK signaling pathways in digestive tract malignancy tumors.
有证据表明，环状RNA（circRNAs）可能通过miRNA反应元件与miRNAs结合，在调节基因表达中发挥重要作用。circRNAs由反向剪接形成，具有共价闭合结构。circRNAs的生物合成似乎也受某些细胞特异性和/或基因特异性机制调控，因此一些circRNAs具有组织特异性和肿瘤表达特异性。此外，circRNAs的高稳定性和组织特异性可能对早期诊断、生存预测和精准医学具有重要价值。本文综述了目前关于circRNAs的分类、功能以及circRNAs在消化道恶性肿瘤中调节PI3K/AKT和/或MEK/ERK信号通路的作用的相关知识。
