National Institute of Oncology, Budapest, Hungary.
National Tumor Laboratory Project, Budapest, Hungary.
Pathol Oncol Res. 2022 Sep 6;28:1610668. doi: 10.3389/pore.2022.1610668. eCollection 2022.
Assessment of population-based cancer survival may provide the most valuable feedback about the effectiveness of oncological surveillance and treatment. Based on the database of the Hungarian National Cancer Registry, standardized incidence rates of lung, breast, colorectal, prostate and cervical cancer were compared to standardized mortality data of the Hungarian Central Statistical Office in the period between 2001 and 2015. Then survival analysis was performed on cleansed database. The incidence of colorectal, breast and prostate cancer increased, while standardized rates of lung and cervical cancer declined. The survival of colorectal, breast and prostate cancer showed improvement. Contrarily, lung cancer exhibited a mild decline, while that of cervical cancer did not change significantly. In earlier stages survival was improved among almost every studied tumor type, while in advanced stages improvement was not observed. Comparison of stage distribution revealed that in the 2011-2015 period colorectal, breast and prostate cancer cases were diagnosed at earlier stages, while lung and cervical cancer patients were typically discovered at more advanced stages. The outcome of advanced cancer treatments is better in earlier stages, which highlighted the importance of screening network. However, growth of oncological treatment costs with longer patient survival imposes a constantly increasing burden on society.
基于人群的癌症生存评估可能提供关于肿瘤监测和治疗效果的最有价值的反馈。基于匈牙利国家癌症登记处的数据库,在 2001 年至 2015 年期间,比较了标准化发病率的肺癌、乳腺癌、结直肠癌、前列腺癌和宫颈癌与匈牙利中央统计局的标准化死亡率数据。然后对净化后的数据库进行了生存分析。结直肠癌、乳腺癌和前列腺癌的发病率增加,而肺癌和宫颈癌的标准化率则下降。结直肠癌、乳腺癌和前列腺癌的生存率有所提高。相反,肺癌的生存率略有下降,而宫颈癌的生存率则没有明显变化。在早期阶段,几乎所有研究的肿瘤类型的生存率都有所提高,而在晚期阶段则没有观察到这种情况。分期分布的比较显示,在 2011-2015 年期间,结直肠癌、乳腺癌和前列腺癌的病例在早期阶段被诊断出来,而肺癌和宫颈癌患者通常在更晚期阶段被发现。晚期癌症治疗的效果在早期阶段更好,这突出了筛查网络的重要性。然而,随着患者生存时间的延长,肿瘤治疗费用的增长给社会带来了不断增加的负担。