Wang Bingfang, Yang Deqi, Chang Zhiqiang, Zhang Ru, Dai Jing, Fang Yin
Research Center for Translational Medicine, Shanghai East Hospital affiliated to Tongji University, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200120, China.
Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital affiliated to Tongji University, Shanghai 200120, China.
Matter. 2022 Dec 7;5(12):4347-4362. doi: 10.1016/j.matt.2022.08.020. Epub 2022 Sep 19.
Respiratory infectious diseases (H1N1, H5N1, COVID-19, etc.) are pandemics that can continually spread in the air through micro-droplets or aerosols. However, the detection of samples in gaseous media is hampered by the requirement for trace amounts and low concentrations. Here, we develop a wearable bioelectronic mask device integrated with ion-gated transistors. Based on the sensitive gating effect of ion gels, our aptamer-functionalized transistors can measure trace-level liquid samples (0.3 μL) and even gaseous media samples at an ultra-low concentration (0.1 fg/mL). The ion-gated transistor with multi-channel analysis can respond to multiple targets simultaneously within as fast as 10 min, especially without sample pretreatment. Integrating a wireless internet of things system enables the wearable mask to achieve real-time and on-site detection of the surrounding air, providing an alert before infection. The wearable bioelectronic masks hold promise to serve as an early warning system to prevent outbreaks of respiratory infectious diseases.
呼吸道传染病（甲型H1N1流感、H5N1禽流感、新型冠状病毒肺炎等）是能够通过微滴或气溶胶在空气中持续传播的大流行病。然而，气态介质中样本的检测受到痕量和低浓度要求的阻碍。在此，我们开发了一种集成离子门控晶体管的可穿戴生物电子口罩装置。基于离子凝胶的灵敏门控效应，我们的适配体功能化晶体管能够测量痕量水平的液体样本（0.3微升），甚至能够检测超低浓度（0.1飞克/毫升）的气态介质样本。具有多通道分析功能的离子门控晶体管能够在短短10分钟内同时对多个目标作出响应，特别是无需进行样本预处理。集成无线物联网系统使可穿戴口罩能够对周围空气进行实时现场检测，在感染前发出警报。这种可穿戴生物电子口罩有望成为预防呼吸道传染病爆发的早期预警系统。
