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针对甲型冠状病毒核衣壳蛋白的 IgG 反应与 COVID-19 严重程度的关联。

Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity.

机构信息

Children's Hospital, School of Medicine, Technische Universität München, Munich, Germany.

German Centre for Infection Research (DZIF) partner site Munich, Munich, Germany.

出版信息

Front Immunol. 2022 Sep 7;13:889836. doi: 10.3389/fimmu.2022.889836. eCollection 2022.

DOI:10.3389/fimmu.2022.889836
PMID:36159804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9490404/
Abstract

Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARS-CoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were measured in SARS-CoV-2-infected donors and healthy controls. COVID-19 severity strongly correlated with IgG responses against the nucleocapsid (N) of SARS-CoV-2 and possibly with the number of viral antigens targeted. Furthermore, a strong correlation between COVID-19 severity and serum responses against N of endemic alpha- but not betacoronaviruses was detected. This correlation was neither caused by cross-reactivity of antibodies, nor by a general boosting effect of SARS-CoV-2 infection on pre-existing humoral immunity. These findings raise the prospect of a potential disease progression marker for COVID-19 severity that allows for early stratification of infected individuals.

摘要

了解针对严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的免疫反应对于控制 COVID-19 大流行至关重要。使用多重分析方法，测量了 SARS-CoV-2 感染供体和健康对照者血清中针对整个 SARS-CoV-2 蛋白组和地方性人类冠状病毒 (HCoV) 核衣壳蛋白的 IgG 反应。COVID-19 的严重程度与针对 SARS-CoV-2 的核衣壳 (N) 的 IgG 反应强烈相关，并且可能与靶向的病毒抗原数量相关。此外，还检测到 COVID-19 严重程度与针对地方性甲型但不是乙型冠状病毒 N 的血清反应之间存在强烈相关性。这种相关性既不是由抗体的交叉反应引起的，也不是 SARS-CoV-2 感染对预先存在的体液免疫的普遍增强作用引起的。这些发现为 COVID-19 严重程度的潜在疾病进展标志物提供了前景，允许对感染个体进行早期分层。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1c/9490404/d366c6136a56/fimmu-13-889836-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1c/9490404/d366c6136a56/fimmu-13-889836-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1c/9490404/fad9358f4576/fimmu-13-889836-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1c/9490404/448580ad66f8/fimmu-13-889836-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1c/9490404/cd4bf5ed7e72/fimmu-13-889836-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1c/9490404/56b6b5ea5edd/fimmu-13-889836-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1c/9490404/d366c6136a56/fimmu-13-889836-g006.jpg

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