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噬菌体Mu诱导的DNA修饰依赖于宿主功能。

Bacteriophage Mu-induced modification of DNA is dependent upon a host function.

作者信息

Khatoon H, Bukhari A I

出版信息

J Bacteriol. 1978 Oct;136(1):423-8. doi: 10.1128/jb.136.1.423-428.1978.

DOI:10.1128/jb.136.1.423-428.1978
PMID:361700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC218675/
Abstract

The DNA of bacteriophage Mu, extracted from induced lysates, is partially resistant to digestion by the endonuclease BalI. This modification of DNA is controlled by the Mu modification function (mom), which acts in conjunction with the dam (DNA-adenine methylation) function of Escherichia coli. Since the BalI recognition site is apparently different from the dam recognition site, these results imply that either the specificity of the dam function is changed by the mom function or the mom function requires the dam function for its activity.

摘要

从诱导裂解物中提取的噬菌体Mu的DNA对核酸内切酶BalI的消化具有部分抗性。DNA的这种修饰由Mu修饰功能（mom）控制，该功能与大肠杆菌的dam（DNA腺嘌呤甲基化）功能共同作用。由于BalI识别位点明显不同于dam识别位点，这些结果表明，要么dam功能的特异性被mom功能改变，要么mom功能的活性需要dam功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a29/218675/b763f498d980/jbacter00287-0435-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a29/218675/11b81dc71ab8/jbacter00287-0432-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a29/218675/938963021167/jbacter00287-0433-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a29/218675/bd15fd819d47/jbacter00287-0434-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a29/218675/b763f498d980/jbacter00287-0435-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a29/218675/11b81dc71ab8/jbacter00287-0432-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a29/218675/938963021167/jbacter00287-0433-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a29/218675/bd15fd819d47/jbacter00287-0434-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a29/218675/b763f498d980/jbacter00287-0435-a.jpg

相似文献

1
Bacteriophage Mu-induced modification of DNA is dependent upon a host function.噬菌体Mu诱导的DNA修饰依赖于宿主功能。
J Bacteriol. 1978 Oct;136(1):423-8. doi: 10.1128/jb.136.1.423-428.1978.
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DNA modification of bacteriophage Mu-1 requires both host and bacteriophage functions.噬菌体Mu-1的DNA修饰需要宿主和噬菌体双方的功能。
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引用本文的文献

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Regulation of bacteriophage Mu transposition.噬菌体Mu转座的调控
Genetica. 1994;93(1-3):27-39. doi: 10.1007/BF01435237.
2
DNA methyltransferase-dependent transcription of the phage Mu mom gene.噬菌体Mu mom基因的DNA甲基转移酶依赖性转录
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5518-21. doi: 10.1073/pnas.79.18.5518.
3
DNA rearrangements associated with reversion of bacteriophage Mu-induced mutations.与噬菌体Mu诱导突变回复相关的DNA重排

本文引用的文献

1
Summary of the genetic mapping of prophage Mu.噬菌体Mu的基因图谱总结
Virology. 1973 Jul;54(1):90-2. doi: 10.1016/0042-6822(73)90117-7.
2
Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose--ethidium bromide electrophoresis.利用分析型琼脂糖-溴化乙锭电泳检测副流感嗜血杆菌中的两种限制性内切酶活性。
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Mapping of the modification function of temperate phage Mu-1.温和噬菌体Mu-1修饰功能的图谱绘制
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6
Purification and characterization of the unusual deoxynucleoside, alpha-N-(9-beta-D-2'-deoxyribofuranosylpurin-6-yl)glycinamide, specified by the phage Mu modification function.由噬菌体Mu修饰功能所指定的异常脱氧核苷α-N-(9-β-D-2'-脱氧呋喃核糖基嘌呤-6-基)甘氨酰胺的纯化与特性鉴定
Proc Natl Acad Sci U S A. 1983 Dec;80(24):7400-4. doi: 10.1073/pnas.80.24.7400.
7
Methylation dependent expression of the mom gene of bacteriophage Mu: deletions downstream from the methylation sites affect expression.噬菌体Mu的mom基因的甲基化依赖性表达：甲基化位点下游的缺失影响表达。
Nucleic Acids Res. 1984 Apr 25;12(8):3535-50. doi: 10.1093/nar/12.8.3535.
8
Bacteriophage survival: multiple mechanisms for avoiding the deoxyribonucleic acid restriction systems of their hosts.噬菌体的存活：避免宿主脱氧核糖核酸限制系统的多种机制。
Microbiol Rev. 1983 Sep;47(3):345-60. doi: 10.1128/mr.47.3.345-360.1983.
9
The products of gene A of the related phages Mu and D108 differ in their specificities.相关噬菌体Mu和D108的基因A产物在特异性上有所不同。
Mol Gen Genet. 1983;190(1):70-9. doi: 10.1007/BF00330326.
10
Unusual modification of bacteriophage Mu DNA.噬菌体Mu DNA的异常修饰
J Virol. 1979 Nov;32(2):468-75. doi: 10.1128/JVI.32.2.468-475.1979.
4
Analysis of bacteriophage mu and lambda-mu hybrid DNAs by specific endonucleases.用特异性核酸内切酶分析噬菌体μ及λ-μ杂种DNA
J Mol Biol. 1975 Mar 15;92(4):529-40. doi: 10.1016/0022-2836(75)90307-1.
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A specific endonuclease from Brevibacterium albidum.来自白色短杆菌的一种特异性核酸内切酶。
J Mol Biol. 1977 Aug 15;114(3):433-40. doi: 10.1016/0022-2836(77)90260-1.
6
DNA modification of bacteriophage Mu-1 requires both host and bacteriophage functions.噬菌体Mu-1的DNA修饰需要宿主和噬菌体双方的功能。
J Virol. 1977 Sep;23(3):825-6. doi: 10.1128/JVI.23.3.825-826.1977.
7
Complementary specificity of restriction endonucleases of Diplococcus pneumoniae with respect to DNA methylation.肺炎双球菌限制性内切核酸酶对DNA甲基化的互补特异性
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