European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton.
CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Protein Sci. 2022 Oct;31(10):e4439. doi: 10.1002/pro.4439.
The archiving and dissemination of protein and nucleic acid structures as well as their structural, functional and biophysical annotations is an essential task that enables the broader scientific community to conduct impactful research in multiple fields of the life sciences. The Protein Data Bank in Europe (PDBe; pdbe.org) team develops and maintains several databases and web services to address this fundamental need. From data archiving as a member of the Worldwide PDB consortium (wwPDB; wwpdb.org), to the PDBe Knowledge Base (PDBe-KB; pdbekb.org), we provide data, data-access mechanisms, and visualizations that facilitate basic and applied research and education across the life sciences. Here, we provide an overview of the structural data and annotations that we integrate and make freely available. We describe the web services and data visualization tools we offer, and provide information on how to effectively use or even further develop them. Finally, we discuss the direction of our data services, and how we aim to tackle new challenges that arise from the recent, unprecedented advances in the field of structure determination and protein structure modeling.
蛋白质和核酸结构的归档和传播，以及它们的结构、功能和生物物理注释，是一项至关重要的任务，它使更广泛的科学界能够在生命科学的多个领域开展有影响力的研究。欧洲蛋白质数据库（PDBe；pdbe.org）团队开发和维护多个数据库和网络服务来满足这一基本需求。从作为全球 PDB 联盟（wwPDB；wwpdb.org）的成员进行数据归档，到 PDBe 知识库（PDBe-KB；pdbekb.org），我们提供数据、数据访问机制和可视化工具，以促进整个生命科学领域的基础和应用研究和教育。在这里，我们提供了我们集成和免费提供的结构数据和注释的概述。我们描述了我们提供的网络服务和数据可视化工具，并提供了有关如何有效使用甚至进一步开发它们的信息。最后，我们讨论了我们的数据服务的方向，以及我们如何努力应对结构测定和蛋白质结构建模领域最近出现的前所未有的进展所带来的新挑战。
