College of Chemistry, Jilin University Alan G. MacDiarmid Institute, 2699 Qianjin Street, Gaoxin District, Changchun 130012, P.R. China.
Inorg Chem. 2022 Oct 17;61(41):16239-16247. doi: 10.1021/acs.inorgchem.2c01896. Epub 2022 Sep 30.
Isoniazid is an antibiotic primarily used in clinical treatment of tuberculosis, but excessive usage can lead to serious consequences such as hepatotoxicity, neurotoxicity, and even coma and death. Therefore, it is critical to exploit a quick, facile, and acute way for isoniazid analysis. In this work, we have demonstrated an efficient electrospinning-carbonation-wet chemistry reaction-calcination process to fabricate CuO/NiO nanotubes (NTs) as a promising nanozyme for peroxidase (POD) mimicking. In virtue of the distinct tubular structure and synergy between CuO and NiO from the mechanisms of both electron transfer and hydroxyl radical generation, a remarkably improved catalytic activity is realized for the CuO/NiO NTs compared with bare CuO and NiO samples. According to the admirable POD-like property, a rapid colorimetric detection for isoniazid is accomplished with a detection limit of 0.4 μM (S/N = 3) and favorable selectivity. In addition, the sensing capability of isoniazid in a real sample is also investigated with satisfactory results. This work offers a novel tactic to fabricate high-performance nanozymes with efficient isoniazid sensing capabilities to address challenges in disease treatment efficacy and public safety monitoring.
异烟肼主要用于临床结核病治疗，但过量使用会导致严重后果，如肝毒性、神经毒性，甚至昏迷和死亡。因此，开发一种快速、简便、灵敏的异烟肼分析方法至关重要。在这项工作中，我们展示了一种有效的静电纺丝-碳酸化-湿化学反应-煅烧工艺，用于制备氧化铜/氧化镍纳米管（NTs），作为一种有前途的过氧化物酶（POD）模拟纳米酶。由于氧化铜和氧化镍之间的电子转移和羟基自由基生成机制的协同作用，CuO/NiO NTs 的催化活性明显优于纯 CuO 和 NiO 样品。根据令人钦佩的 POD 样性质，CuO/NiO NTs 可实现快速比色检测异烟肼，检测限为 0.4 μM（S/N = 3），具有良好的选择性。此外，还研究了该传感器在实际样品中对异烟肼的检测能力，结果令人满意。这项工作为制备具有高效异烟肼传感能力的高性能纳米酶提供了一种新策略，以解决疾病治疗效果和公共安全监测方面的挑战。
